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Abbokinase (Abbott Laboratories)

Abbokinase (Abbott Laboratories) - General Information

Low molecular weight form of human urokinase, that consists of an A chain of 2,000 daltons linked by a sulfhydryl bond to a B chain of 30,400 daltons. Recombinant urokinase plasminogen activator

 

Pharmacology of Abbokinase (Abbott Laboratories)

Abbokinase (Abbott Laboratories) is used for the treatment of pulmonary embolisms. The low molecular weight form of human urokinase consists of an A chain of 2,000 daltons linked by a sulfhydryl bond to a B chain of 30,400 daltons. Abbokinase (Abbott Laboratories) is an enzyme (protein) produced by the kidney, and found in the urine. There are two forms of urokinase which differ in molecular weight but have similar clinical effects. Abbokinase (Abbott Laboratories) is the low molecular weight form. Abbokinase (Abbott Laboratories) acts on the endogenous fibrinolytic system. It converts plasminogen to the enzyme plasmin. Plasmin degrades fibrin clots as well as fibrinogen and some other plasma proteins.

 

Additional information about Abbokinase (Abbott Laboratories)

Abbokinase (Abbott Laboratories) Indication: For the treatment of pulminary embolism, coronary artery thrombosis and IV catheter clearance
Mechanism Of Action: Abbokinase (Abbott Laboratories) acts on the endogenous fibrinolytic system. It cleaves the Arg-Val bond in plasminogen to produce active plasmin. Plasmin degrades fibrin clots as well as fibrinogen and other plasma proteins.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Urokinase
Synonyms: U-plasminogen activator; Urokinase-type plasminogen activator precursor; uPA
Drug Category: Thrombolytic Agents
Drug Type: Biotech; Approved
Other Brand Names containing Urokinase: Abbokinase (Abbott Laboratories)
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Proteolysis
Half Life: 12 minutes. Small fractions of the administered dose are excreted in bile and urine
Dosage Forms of Abbokinase (Abbott Laboratories): Powder, for solution Intravenous
Chemical IUPAC Name: Human urokinase
Chemical Formula: C1376H2145N383O406S18
Urokinase on Wikipedia: http://en.wikipedia.org/wiki/Urokinase
Organisms Affected: Humans and other mammals