Abreva - General Information
Abreva is a drug used for topical treatment for recurrent herpes simplex labialis episodes (episodes of cold sores or fever blisters). A saturated 22-carbon aliphatic alcohol, docosanol exhibits antiviral activity against many lipid enveloped viruses including herpes simplex virus (HSV). Abreva inhibits fusion between the plasma membrane and the herpes simplex virus (HSV) envelope, thereby preventing viral entry into cells and subsequent viral replication.
Pharmacology of Abreva
Abreva is a saturated 22-carbon aliphatic alcohol which exhibits antiviral activity against many lipid enveloped viruses including herpes simplex virus (HSV). Abreva speeds the healing of cold sores and fever blisters on the face or lips. It also relieves the accompanying symptoms, including tingling, pain, burning, and itching. Abreva cannot, however, prevent cold sores or fever blisters from appearing.
Additional information about Abreva
Abreva Indication: For the topical treatment of recurrent oral-facial herpes simplex episodes (cold sores or fever blisters).
Mechanism Of Action: Abreva works by inhibiting fusion between the human cell plasma membrane and the herpes simplex virus (HSV) envelope, thereby preventing viral entry into cells and subsequent viral replication. Unlike other cold-sore antivirals, docosanol does not act directly on the virus, and as such it is unlikely it will produce drug resistant mutants of HSV.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Docosanol
Synonyms: Behenyl alcohol
Drug Category: Dermatologicals; Antiviral Agents
Drug Type: Small Molecule; Approved; Investigational
Other Brand Names containing Docosanol: Abreva;
Absorption: Topical absorption has been shown to be minimal under conditions reflecting normal clinical use.
Toxicity (Overdose): Symptoms of overdose include headache, abdominal pain, increased serum lipase, nausea, dyspepsia, dizziness, and hyperbilirubinemia.
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Abreva: Cream Topical
Chemical IUPAC Name: docosan-1-ol
Chemical Formula: C22H46O
Docosanol on Wikipedia: http://en.wikipedia.org/wiki/Docosanol
Organisms Affected: Herpes simplex virus