Absentol - General Information
An anticonvulsant effective in absence seizures, but generally reserved for refractory cases because of its toxicity. (From AMA Drug Evaluations Annual, 1994, p378)
Pharmacology of Absentol
Paramethadione and trimethadione are anticonvulsants indicated in the control of absence (petit mal) seizures that are refractory to treatment with other medications. Dione anticonvulsants are used in the treatment of epilepsy. They act on the central nervous system (CNS) to reduce the number of seizures.
Absentol for patients
Contraindicated in liver disease, kidney disease, retinal or optic nerve (eye) disease, a disease of the blood or bone marrow, and acute intermittent porphyria.
Additional information about Absentol
Absentol Indication: Used in the control of absence (petit mal) seizures that are refractory to treatment with other medications.
Mechanism Of Action: Dione anticonvulsants reduce T-type calcium currents in thalamic neurons, including thalamic relay neurons. This raises the threshold for repetitive activity in the thalamus, and inhibits corticothalamic transmission. Thus, the abnormal thalamocortical rhythmicity, which is thought to underlie the 3-Hz spike-and-wave discharge seen on electroencephalogram(EEG) with absence seizures, is dampened.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Trimethadione
Synonyms: Trimethadion; Trimetadione; Trimethdione
Drug Category: Anticonvulsants
Drug Type: Small Molecule; Approved
Other Brand Names containing Trimethadione: Absentol; Absetil; Convenixa; Convexina; Edion; Epidione; Epidone; Epixal; Etydion; Mino-Aleviatin; Minoaleuiatin; Minoaleviatin; Neo-Absentol; Petidion; Petidon; Petilep; Petimalin; Pitmal; Ptimal; Tioxanona; Tredione; Tricione; Tridilona; Tridion; Tridione; Tridone; Trilidona; Trimedal; Trimedone; Trimethin; Trimetin; Trioxanona; Triozanona; Tromedone; Troxidone;
Absorption: Not Available
Toxicity (Overdose): Symptoms of overdose include clumsiness or unsteadiness, coma, dizziness (severe), drowsiness (severe), nausea (severe), and problems with vision.
Protein Binding: 90%
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Absentol: Not Available
Chemical IUPAC Name: 3,5,5-trimethyl-1,3-oxazolidine-2,4-dione
Chemical Formula: C6H9NO3
Trimethadione on Wikipedia: http://en.wikipedia.org/wiki/Trimethadione
Organisms Affected: Humans and other mammals