Achromycin V - General Information
A naphthacene antibiotic that inhibits amino acyl TRNA binding during protein synthesis.
Pharmacology of Achromycin V
Achromycin V is a short-acting antibiotic semisynthetically produced from chlortetracycline, which is derived from Streptomyces aureofaciens. Achromycin V inhibits cell growth by inhibiting translation. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome. This binding is reversible in nature.
Achromycin V for patients
When Actisite® fiber is in place, patients should avoid actions that may dislodge the fiber. Patients should receive the following instructions:
- Do not chew hard, crusty, or sticky foods.
- Do not brush or floss near any treated areas. (Continue to clean other teeth.)
- Do not engage in any other hygienic practices that could potentially dislodge the fibers.
- Do not probe at the treated area with tongue or fingers.
- Notify the dentist promptly if the fiber is dislodged or falls out before the scheduled recall visit, or if pain or swelling or other problems occur.
Achromycin V Interactions
Interaction may occur with Antacids, Calcium supplements, Cholestyramine, Choline and
magnesium salicylates, Colestipol, Iron-containing drugs, Laxatives, Magnesium
salicylate: these drugs may decrease the potency of tetracyclines. Oral contraceptives
containing estrogen: tetracyclines may decrease the contraceptive effect and increase the
chance of unwanted pregnancy.
Achromycin V Contraindications
Actisite fiber should not be used in patients who are hypersensitive to any tetracycline.
Additional information about Achromycin V
Achromycin V Indication: Used to treat bacterial infections such as Rocky Mountain spotted fever, typhus fever, and tick fevers; upper respiratory infections; pneumonia; gonorrhea; amoebic infections; and urinary tract infections. It is also used to help treat severe acne and to treat trachoma (a chronic eye infection) and conjunctivitis (pinkeye). Achromycin V is often an alternative drug for people who are allergic to penicillin.
Mechanism Of Action: Achromycin V passively diffuses through porin channels in the bacterial membrane and reversibly binds to the 30S ribosomal subunit, preventing binding of tRNA to the mRNA-ribosome complex, and thus interfering with protein synthesis.
Drug Interactions: Not Available
Food Interactions: Avoid milk, calcium containing dairy products, iron, antacids, or aluminium salts 2 hours before or 6 hours after using antacids while on this medication.
Take on empty stomach: 1 hour before or 2 hours after meals.
Take with a full glass of water.
Generic Name: Tetracycline
Synonyms: Tetracycline HCl; TC; Anhydrotetracycline
Drug Category: Anti-Bacterial Agents; Antiprotozoals; Tetracyclines
Drug Type: Small Molecule; Approved
Other Brand Names containing Tetracycline: Abramycin; Abricycline; Achromycin; Achromycin V; Actisite; Agromicina; Ambramicina; Ambramycin; Amycin; Bio-Tetra; Biocycline; Bristaciclin; Bristaciclina; Bristacycline; Cefracycline; Ciclibion; Copharlan; Criseociclina; Cyclopar; Cytome; Democracin; Deschlorobiomycin; Dumocyclin; Enterocycline; Hostacyclin; Lexacycline; Limecycline; Liquamycin; Medocycline; Mericycline; Micycline; Neocycline; Oletetrin; Omegamycin; Orlycycline; Panmycin; Polycycline; Polyotic; Purocyclina; Resteclin; Retet; Robitet; Roviciclina; SK-Tetracycline; Solvocin; Sumycin; TAC; Tetra-CO; Tetrabon; Tetrachel; Tetracycl; Tetracycline II; Tetracyn; Tetradecin; Tetrafil; Tetramed; Tetraverine; Tetrex; Topicycline; Tsiklomistsin; Tsiklomitsin; Veracin; Vetacyclinum;
Absorption: Bioavailability is less than 40% when administered via intramuscular injection, 100% intravenously, and 60-80% orally (fasting adults). Food and/or milk reduce GI absorption of oral preparations of tetracycline by 50% or more.
Toxicity (Overdose): LD50=808mg/kg (orally in mice)
Protein Binding: Tetracyclines bind to plasma proteins to varying degrees
Biotransformation: Not metabolized
Half Life: 6-11 hours
Dosage Forms of Achromycin V: Tablet Oral
Chemical IUPAC Name: (2Z)-2-(amino-hydroxymethylidene)-4-dimethylamino-6,10,11,12a-tetrahydroxy-6-methyl-4,4a,5,5a-tetrahydrotetracene-1,3,12-trione
Chemical Formula: C22H24N2O8
Tetracycline on Wikipedia: http://en.wikipedia.org/wiki/Tetracycline
Organisms Affected: Enteric bacteria and other eubacteria