Aclovate - General Information

Aclovate is synthetic glucocorticoid steroid for topical use in dermatology as anti-inflammatory, antipruritic, antiallergic, antiproliferative and vasoconstrictive agent. [Wikipedia]


Pharmacology of Aclovate

Aclovate is a synthetic corticosteroid for topical dermatologic use. The corticosteroids constitute a class of primarily synthetic steroids used topically as anti-inflammatory and antipruritic agents. Aclovate is a selective glucocorticoid receptor agonist.


Aclovate for patients

Patients using topical corticosteroids should receive the following information and instructions:

1. This medication is to be used as directed by the physician. It is for external use only. Avoid contact with the eyes.

2. This medication should not be used for any disorder other than that for which it was prescribed.

3. The treated skin area should not be bandaged, otherwise covered or wrapped so as to be occlusive, unless directed by the physician.

4. Patients should report to their physician any signs of local adverse reactions.

5. Parents of pediatric patients should be advised not to use ACLOVATE Cream or Ointment in the treatment of diaper dermatitis. ACLOVATE Cream or Ointment should not be applied in the diaper area as diapers or plastic pants may constitute occlusive dressing.

6. This medication should not be used on the face, underarms, or groin areas unless directed by the physician.

7. As with other corticosteroids, therapy should be discontinued when control is achieved. If no improvement is seen within 2 weeks, contact the physician.


Aclovate Interactions

No information provided


Aclovate Contraindications

ACLOVATE Cream and Ointment are contraindicated in those patients with a history of hypersensitivity to any of the components in these preparations.


Additional information about Aclovate

Aclovate Indication: For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.
Mechanism Of Action: The mechanism of the anti-inflammatory activity of the topical steroids, in general, is unclear. However, corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor, arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2. Aclovate also binds the corticosteroid receptor.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Alclometasone
Synonyms: Alclometasone dipropionate
Drug Category: Corticosteroids; Anti-inflammatory Agents; Antipruritic Agents
Drug Type: Small Molecule; Approved
Other Brand Names containing Alclometasone: Aclovate;
Absorption: Topical corticosteroids can be absorbed from normal intact skin. Studies have shown that approximately 3% of steroid is absorbed during 8 hours of contact with intact skin of normal volunteers.
Toxicity (Overdose): Symptoms of overdose include suppression of adrenal glands, temporary decrease in white blood cell counts, symptoms of hypersensitivity (such as skin rash, hives, itching, and difficulty breathing), and increased susceptibility to infection.
Protein Binding: Not Available
Biotransformation: Hepatic.
Half Life: Not Available
Dosage Forms of Aclovate: Cream Topical
Ointment Topical
Chemical IUPAC Name: [(7R,8S,9S,10R,11S,13S,14S,16R,17R)-7-chloro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(2-propanoyloxyacetyl)-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl] propanoate
Chemical Formula: C28H37ClO7
Alclometasone on Wikipedia:
Organisms Affected: Humans and other mammals