Acocantherin - General Information
A cardioactive glycoside consisting of rhamnose and ouabagenin, obtained from the seeds of Strophanthus gratus and other plants of the Apocynaceae; used like digitalis. It is commonly used in cell biological studies as an inhibitor of the NA(+)-K(+)-exchanging ATPase.
Pharmacology of Acocantherin
Acocantherin, a cardiac glycoside similar to digitoxin, is used to treat congestive heart failure and supraventricular arrhythmias due to reentry mechanisms, and to control ventricular rate in the treatment of chronic atrial fibrillation.
Additional information about Acocantherin
Acocantherin Indication: For the treatment of atrial fibrillation and flutter and heart failure
Mechanism Of Action: Acocantherin inhibits the Na-K-ATPase membrane pump, resulting in an increase in intracellular sodium and calcium concentrations. Increased intracellular concentrations of calcium may promote activation of contractile proteins (e.g., actin, myosin). Acocantherin also acts on the electrical activity of the heart, increasing the slope of phase 4 depolarization, shortening the action potential duration, and decreasing the maximal diastolic potential.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Ouabain
Synonyms: Ouabain Octahydrate; Ouabain, Octahydrate; Ouabaine; G-Strophanthin; Ouabagenin L-Rhamnoside; Strophanthin G; Strophanthin-G
Drug Category: Cardiotonic Agents
Drug Type: Small Molecule; Approved
Other Brand Names containing Ouabain: Acocantherin; Astrobain; G-Strophicor; Gratibain; Gratus Strophanthin; Kombetin; Purostrophan; Rectobaina; Solufantina; Strodival; Strophalen; Strophoperm; Strophosan; Uabaina; Uabanin;
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: 60%
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Acocantherin: Not Available
Chemical IUPAC Name: 4-[(1R,3S,5S,8R,9S,10R,11R,13R,14S,17R)-1,5,11,14-tetrahydroxy-10-(hydroxymethyl)-13-methyl-3-[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-5H-furan-2-one
Chemical Formula: C29H44O12
Ouabain on Wikipedia: http://en.wikipedia.org/wiki/Ouabain
Organisms Affected: Humans and other mammals