Actidil - General Information

Histamine H1 antagonist used in allergic rhinitis; asthma; and urticaria. It is a component of cough and COLD medicines. It may cause drowsiness.


Pharmacology of Actidil

In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils. Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell-degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. Once released, histamine can react with local or widespread tissues through histamine receptors. Histamine, acting on H1-receptors, produces pruritis, vasodilatation, hypotension, flushing, headache, tachycardia, and bronchoconstriction. Histamine also increases vascular permeability and potentiates pain. Actidil, is a histamine H1 antagonist that competes with histamine for the normal H1-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies.


Actidil for patients

Stop taking triprolidine 4 days before you have an allergy skin test. Drink water frequently or use ice chips, sugarless candy, or sugarless gum if dry mouth occurs. Coffee or tea may reduce the common side effect of drowsiness.


Actidil Interactions

Triprolidine may enhance the sedative effects of central nervous system depressants including alcohol, barbiturates, hypnotics, narcotic analgesics, sedatives, and tranquillisers. The effects of anticholinergic drugs, such as atropine and tricyclic antidepressants may be enhanced by the concomitant administration of triprolidine. Triprolidine may effect the metabolism of drugs in the liver.


Actidil Contraindications

Should not be administered to patients suffering from cardiovascular disease (especially coronary insufficiency), hypertension, prostatism, thyrotoxicosis, bladder dysfunction, narrow angle glaucoma, phaeochromocytoma and during an attack of asthma in asthmatic patients.


Additional information about Actidil

Actidil Indication: For the treatment of hay fever, urticaria (hives), and other allergic systems.
Mechanism Of Action: Actidil binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Triprolidine
Synonyms: Not Available
Drug Category: Anti-Allergic Agents
Drug Type: Small Molecule; Approved
Other Brand Names containing Triprolidine: Actidil; Myidyl; Triprolidine HCL; Triprolidine Hydrochloride; Venen (TN);
Absorption: Rapidly absorbed in the intestinal tract.
Toxicity (Overdose): Symptoms of overdose include drowsiness, weakness, inco-ordination, difficulty with micturition, respiratory depression, hypotension, agitation, irritability, convulsions, hypertension, palpitation and tachycardia.
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: 4 to 6 hours.
Dosage Forms of Actidil: Not Available
Chemical IUPAC Name: 2-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridine
Chemical Formula: C19H22N2
Triprolidine on Wikipedia:
Organisms Affected: Humans and other mammals