Adagen (Enzon Inc.) - General Information
Bovine adenosine deaminase derived from bovine intestine that has been extensively pegylated for extended serum half life
Pharmacology of Adagen (Enzon Inc.)
Used to replace deficient or inactive adenosine deaminase which leads to severe combined immunodeficiency disease (SCID). The enzyme is responsible for converting adenosine to inosine. In the absence of adenosine deaminase, the purine substrates adenosine, 2'-deoxyadenosine and their metabolites are actually toxic to lymphocytes thereby leading to diminished immune function.
Adagen (Enzon Inc.) for patients
Adagen (Enzon Inc.) Interactions
There are no known drug interactions with ADAGEN� (pegademase bovine) Injection. However, Vidarabine is a substrate for ADA and 2'-deoxycoformycin is a potent inhibitor of ADA. Thus, the activities of these drugs and ADAGEN� (pegademase bovine) Injection could be substantially altered if they are used in combination with one another.
Adagen (Enzon Inc.) Contraindications
There is no evidence to support the safety and efficacy of ADAGEN� (pegademase bovine) Injection as preparatory or support therapy for bone marrow transplantation. Since ADAGEN� (pegademase bovine) Injection is administered by intramuscular injection, it should be used with caution in patients with thrombocytopenia and should not be used if thrombocytopenia is severe.
Additional information about Adagen (Enzon Inc.)
Adagen (Enzon Inc.) Indication: For treatment of adenosine deaminase deficiency
Mechanism Of Action: Pegademase converts adenosine (toxic) to inosine (less toxic) by deamination. It also converts 2'-deoxyadenosine to 2'-deoxyinosine via deamination.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Pegademase bovine
Synonyms: Adenosine aminohydrolase; Adenosine deaminase
Drug Category: Enzyme Replacement Agents
Drug Type: Biotech; Approved
Other Brand Names containing Pegademase bovine: Adagen (Enzon Inc.);
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Adagen (Enzon Inc.): Injection, solution Intramuscular
Chemical IUPAC Name: bovine adenosine deaminase (PEGylated)
Chemical Formula: C1821H2834N484O552S14
Pegademase bovine on Wikipedia: Not Available
Organisms Affected: Humans and other mammals