Adumbran - General Information
A benzodiazepine used in the treatment of anxiety, alcohol withdrawal, and insomnia.
Pharmacology of Adumbran
Adumbran is a drug which is a benzodiazepine derivative. It possesses relatively weak anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties.
Adumbran for patients
To assure the safe and effective use of oxazepam, patients should be informed that, since benzodiazepines may produce psychological and physical dependence, it is advisable that they consult with their physician before either increasing the dose or abruptly discontinuing this drug.
No information provided.
Additional information about Adumbran
Adumbran Indication: For the treatment of anxiety disorders.
Mechanism Of Action: Adumbran is believed to stimulate GABA receptors in the ascending reticular activating system. Since GABA is inhibitory, receptor stimulation increases inhibition and blocks both cortical and limbic arousal following stimulation of the brain stem reticular formation.
Drug Interactions: Clozapine Increased risk of toxicity
Ethotoin Possible increased levels of the hydantoin, decrease of benzodiazepine
Fosphenytoin Possible increased levels of the hydantoin, decrease of benzodiazepine
Mephenytoin Possible increased levels of the hydantoin, decrease of benzodiazepine
Phenytoin Possible increased levels of the hydantoin, decrease of benzodiazepine
Kava Kava increases the effect of the benzodiazepine
Food Interactions: Avoid alcohol.
Take with food.
Avoid excessive quantities of coffee or tea (Caffeine).
Generic Name: Oxazepam
Synonyms: d-Oxazepam hemisuccinate; Oxozepam; Oxazipam
Drug Category: Anti-anxiety Agents; GABA Modulators; Hypnotics and Sedatives
Drug Type: Small Molecule; Approved
Other Brand Names containing Oxazepam: Adumbran; Ansioxacepam; Anxiolit; Aplakil; Astress; Azutranquil; Bonare; Drimuel; Droxacepam; Durazepam; Enidrel; Hi-Long; Isodin; Lederpam; Limbial; Murelax; Nesontil; Noctazepam; Notaral; Oxa-puren; Oxanid; Pacienx; Praxiten; Propax; Psiquiwas; QUEN; Quilibrex; Rondar; Sedigoa; Serax; Serenal; Serenid; Serenid-D; Serepax; Seresta; Serpax; Sigacalm; Sobril; Tacepam; Tazepam; Uskan; Vaben; Wy-3498 stic; Zaxopam;
Absorption: Well absorbed from the gastrointestinal tract following oral administration.
Toxicity (Overdose): Symptoms of overdose include confusion, drowsiness, and lethargy.
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: 5.7 to 10.9
Dosage Forms of Adumbran: Tablet Oral
Chemical IUPAC Name: 7-chloro-3-hydroxy-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one
Chemical Formula: C15H11ClN2O2
Oxazepam on Wikipedia: http://en.wikipedia.org/wiki/Oxazepam
Organisms Affected: Humans and other mammals