Akpentolate - General Information
A parasympatholytic anticholinergic used solely to obtain mydriasis or cycloplegia.
Pharmacology of Akpentolate
Akpentolate is an anti-muscarinic in the same class as atropine and scopolamine. Akpentolate blocks the receptors in the muscles of the eye (muscarinic receptors). These receptors are involved controlling the pupil size and the shape of the lens. Akpentolate thus induces relaxation of the sphincter of the iris and the ciliary muscles. When applied topically to the eyes, it causes a rapid, intense cycloplegic and mydriatic effect that is maximal in 15 to 60 minutes; recovery usually occurs within 24 hours. The cycloplegic and mydriatic effects are slower in onset and longer in duration in patients who have dark pigmented irises.
Akpentolate for patients
Patients should be advised not to drive or engage in other hazardous activities while pupils are dilated. Patients may experience sensitivity to light and should protect eyes in bright illumination during dilation. Parents should be warned not to get this preparation in their child's mouth and to wash their own hands and the child's hands following administration. Do not touch the dropper tip to any surface as this may contaminate the solution. A transient burning sensation may occur upon instillation.
Cyclopentolate may interfere with the anti-glaucoma action of carbachol or pilocarpine; also, concurrent use of this medication may antagonise the anti-glaucoma and miotic actions of ophthalmic cholinesterase inhibitors.
Cyclopentolate is contraindicated in patients with angle-closure glaucoma or in patients with shallow anterior chambers
Additional information about Akpentolate
Akpentolate Indication: Used mainly to produce mydriasis and cycloplegia for diagnostic purposes.
Mechanism Of Action: By blocking muscarinic receptors, cyclopentolate produces dilatation of the pupil (mydriasis) and prevents the eye from accommodating for near vision (cycloplegia).
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Cyclopentolate
Synonyms: Ciclopentolato [INN-Spanish]; Cyclopentolate HCL; Cyclopentolatum [INN-Latin]; Cyclopentylate; Cyclopentoiate; Diopentolate
Drug Category: Antimuscarinic eye preparations; Muscarinic Antagonists; Mydriatics; Parasympatholytics
Drug Type: Small Molecule; Approved
Other Brand Names containing Cyclopentolate: AK-Pentolate; Akpentolate; Cyclogyl; Cylate; Minims Cyclopentolate; Mydrilate; Ocu-Pentolate; Pentolair;
Absorption: Absorbed following ophthalmic administration.
Toxicity (Overdose): Oral LD50 in the rat is 4000 mg/kg and 960 mg/kg in the mouse. Symptoms of overdose include tachycardia, dizziness, dry mouth, behavioral disturbances, uncoordination and drowsiness.
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Akpentolate: Solution / drops Ophthalmic
Chemical IUPAC Name: 2-dimethylaminoethyl 2-(1-hydroxycyclopentyl)-2-phenylacetate
Chemical Formula: C17H25NO3
Cyclopentolate on Wikipedia: http://en.wikipedia.org/wiki/Cyclopentolate
Organisms Affected: Humans and other mammals