Albucid - General Information
An anti-infective agent that is used topically to treat skin infections and orally for urinary tract infections.
Pharmacology of Albucid
Albucid is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.
Albucid for patients
To avoid contamination, do not touch lip of container to eye, eyelid or any surface.
Sulfacetamide preparations are incompatible with silver preparations.
Hypersensitivity to sulfonamides or to any ingredient of this preparation.
Additional information about Albucid
Albucid Indication: For the treatment of bacterial vaginitis, keratitis, acute conjunctivitis, and blepharitis.
Mechanism Of Action: Albucid is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), an essential component for bacterial growth (according to the Woods-Fildes theory). The inhibited reaction is necessary in these organisms for the synthesis of folic acid.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Sulfacetamide
Synonyms: Not Available
Drug Category: Anti-Bacterial Agents; Anti-Infective Agents, Local; Anti-Infective Agents, Urinary
Drug Type: Small Molecule; Approved
Other Brand Names containing Sulfacetamide: Acetocid; Acetosulfamin; Acetosulfamine; Ak-Sulf; Albamine; Albucid; Alesten; Bleph-10; Bleph-10 Liquifilm; Cetamide; Formosulfacetamide; Gyne-Sulf; I-Sulfacet; Isopto Cetamide; Isopto-Cetamide; Klaron; N'-Acetylsulfanilamide; N-Acetylsulfanilamide; N-Acetylsulfanilamine; N-Sulfanilylacetamide; N-Sulphanilylacetamide; Oclucid; Ocusulf-10; Op-Sulfa 30; Ophthacet; Ophthel-S; P-Aminobenzenesulfonacetamide; P-Aminobenzenesulfonoacetamide; Region; Sebizon; Sodium Sulamyd; Sodium Sulfacetamide; Steramide; Steri-Units Sulfacetamide; Sulamyd; Sulf-10; Sulf-15; Sulfacel-15; Sulfacet; Sulfacetamide Sodium; Sulfacetamide Sodium Anhydrous; Sulfacetamide Sodium Usp; Sulfacetimide; Sulfacyl; Sulfair; Sulfair 10; Sulfair 15; Sulfair Forte; Sulfair-15; Sulfamide; Sulfanilacetamide; Sulfanilazetamid; Sulfex; Sulphacetamide; Sulphacetamide Sodium; Sulphasil; Sulten-10; Sultrin; Trysul; Urosulfon; Urosulfone;
Absorption: Not Available
Toxicity (Overdose): Oral LD50 Mouse : 16500 mg/kg. Side effects include moderate to severe erythema (redness) and moderate edema (raised kin), nausea, vomiting, headache, dizziness, and tiredness. Higher exposure causes unconsciousness.
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: 7-12.8 hours
Dosage Forms of Albucid: Solution / drops Ophthalmic
Chemical IUPAC Name: N-(4-aminophenyl)sulfonylacetamide
Chemical Formula: C8H10N2O3S
Sulfacetamide on Wikipedia: http://en.wikipedia.org/wiki/Sulfacetamide
Organisms Affected: Enteric bacteria and other eubacteria