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Aldurazyme (Biomarin Pharmaceuticals)

Aldurazyme (Biomarin Pharmaceuticals) - General Information

Human recombinant alpha-L-iduronidase, 628 residues (mature form), produced by recombinant DNAtechnology in a Chinese hamster ovary cell line. Aldurazyme (Biomarin Pharmaceuticals) is a glycoprotein with a molecular weight of approximately 83 kD. The predicted amino acid sequence of the recombinant form, as well as the nucleotide sequence that encodes it, are identical to a polymorphic form of human a-L-iduronidase. It contains 6 N-linked oligosaccharide modification sites.

 

Pharmacology of Aldurazyme (Biomarin Pharmaceuticals)

Aldurazyme (Biomarin Pharmaceuticals) is used to treat mucopolysaccharide storage disorders (specifically mucopolysaccharidosis 1 or Hurlers syndrome) caused by deficiencies of alpha-L-iduronidase. Reduced or absent a-L-iduronidase activity results in the accumulation of the GAG substrates, dermatan sulfate and heparan sulfate, throughout the body and leads to widespread cellular, tissue, and organ dysfunction.

 

Aldurazyme (Biomarin Pharmaceuticals) for patients

 

Aldurazyme (Biomarin Pharmaceuticals) Interactions

No formal drug interaction studies have been conducted.

 

Aldurazyme (Biomarin Pharmaceuticals) Contraindications

There are no known contraindications to the use of ALDURAZYME.

 

Additional information about Aldurazyme (Biomarin Pharmaceuticals)

Aldurazyme (Biomarin Pharmaceuticals) Indication: For the treatment of mucopolysaccharidosis
Mechanism Of Action: Aldurazyme (Biomarin Pharmaceuticals) catalyses the hydrolysis of terminal alpha-L-iduronic acid residues of dermatan sulfate and heparin sulfate.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Laronidase
Synonyms: Alpha-L-iduronidase precursor
Drug Category: Enzyme Replacement Agents
Drug Type: Biotech; Approved
Other Brand Names containing Laronidase: Aldurazyme (Biomarin Pharmaceuticals);
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: 1.5-3.6 hrs
Dosage Forms of Aldurazyme (Biomarin Pharmaceuticals): Solution Intravenous
Chemical IUPAC Name: Human alpha-L-iduronidase
Chemical Formula: C3160H4848N898O881S12
Laronidase on Wikipedia: http://en.wikipedia.org/wiki/Laronidase
Organisms Affected: Humans and other mammals