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Alferon (Interferon Sciences Inc.)

Alferon (Interferon Sciences Inc.) - General Information

Purified, natural (n is for natural) human interferon alpha proteins (consists of 3 forms or polymorphisms including 2a, 2b and 2c). 166 residues, some are glycosylated (MW range from 16 kD to 27 kD)

 

Pharmacology of Alferon (Interferon Sciences Inc.)

Alferon (Interferon Sciences Inc.) upregulates the expression of MHC I proteins, allowing for increased presentation of peptides derived from viral antigens. This enhances the activation of CD8+ T cells that are the precursors for cytotoxic T lymphocytes (CTLs) and makes the macrophage a better target for CTL-mediated killing. Interferon alpha also induce the synthesis of several key antiviral mediators, including 2'-5' oligoadenylate synthetase (2'-5' A synthetase), beta-2 microglobulin, neopterin and protein kinase R.

 

Additional information about Alferon (Interferon Sciences Inc.)

Alferon (Interferon Sciences Inc.) Indication: For the treatment of hairy cell leukemia, malignant melanoma, AIDS-related Kaposi's sarcoma, refractory or recurring external condylomata acuminata in patients 18 years of age or older, laryngeal papillomatosis in children and some types of hepatitis
Mechanism Of Action: Interferon alpha binds to type I interferon receptors (IFNAR1 and IFNAR2c) which, upon dimerization, activate two Jak (Janus kinase) tyrosine kinases (Jak1 and Tyk2). These transphosphorylate themselves and phosphorylate the receptors. The phosphorylated INFAR receptors then bind to Stat1 and Stat2 (signal transducers and activators of transcription) which dimerize and activate multiple (~100) immunomodulatory and antiviral proteins. Interferon alpha binds less stably to type I interferon receptors than interferon beta.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Interferon alfa-n3
Synonyms: Interferon alpha-2 precursor; Interferon alpha-A; LeIF A
Drug Category: Antineoplastic Agents; Antiviral Agents; Immunomodulatory Agents
Drug Type: Biotech; Approved; Investigational
Other Brand Names containing Interferon alfa-n3: Alferon (Interferon Sciences Inc.);
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Alferon (Interferon Sciences Inc.): Not Available
Chemical IUPAC Name: Human interferon alpha (2a, 2b and 2c)
Chemical Formula: C860H1353N227O255S9
Interferon alfa-n3 on Wikipedia: Not Available
Organisms Affected: Not Available