Ambochlorin - General Information
A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin&
Pharmacology of Ambochlorin
Ambochlorin is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Alkylating agents are cell cycle-nonspecific. Alkylating agents work by three different mechanisms all of which achieve the same end result - disruption of DNA function and cell death.
Ambochlorin for patients
There are no known drug/drug interactions with chlorambucil.
Chlorambucil should not be used in patients whose disease has demonstrated a prior resistance to the agent. Patients who have demonstrated hypersensitivity to chlorambucil should not be given the drug.There may be cross-hypersensitivity (skin rash) between chlorambucil and other alkylating agents.
Additional information about Ambochlorin
Ambochlorin Indication: For treatment of chronic lymphatic (lymphocytic) leukemia, malignant lymphomas including lymphosarcoma, giant follicular lymphoma, and Hodgkin's disease
Mechanism Of Action: Alkylating agents work by three different mechanisms: 1) attachment of alkyl groups to DNA bases, resulting in the DNA being fragmented by repair enzymes in their attempts to replace the alkylated bases, preventing DNA synthesis and RNA transcription from the affected DNA, 2) DNA damage via the formation of cross-links (bonds between atoms in the DNA) which prevents DNA from being separated for synthesis or transcription, and 3) the induction of mispairing of the nucleotides leading to mutations.
Drug Interactions: Not Available
Food Interactions: Take on an empty stomach.
Food reduces bioavailability.
Generic Name: Chlorambucil
Synonyms: Chloraminophen; Chloraminophene; Phenylbutyric Acid Nitrogen Mustard; Chlorobutine; Chlorobutin; Chloroambucil; Chlorbutine; Chlorbutin; Chlocambucil
Drug Category: Antineoplastic Agents
Drug Type: Small Molecule; Approved
Other Brand Names containing Chlorambucil: Ambochlorin; Amboclorin; Ecloril; Elcoril; Leukeran; Leukeran Tablets; Leukersan; Leukoran; Linfolizin; Linfolysin; Pepstatin;
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: 99%
Biotransformation: Not Available
Half Life: 1.5 hours
Dosage Forms of Ambochlorin: Tablet Oral
Chemical IUPAC Name: 4-[4-[bis(2-chloroethyl)amino]phenyl]butanoic acid
Chemical Formula: C14H19Cl2NO2
Chlorambucil on Wikipedia: http://en.wikipedia.org/wiki/Chlorambucil
Organisms Affected: Humans and other mammals