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Aminouracil Mustard

Aminouracil Mustard - General Information

Nitrogen mustard derivative of uracil. It is a alkylating antineoplastic agent that is used in lymphatic malignancies, and causes mainly gastrointestinal and bone marrow damage.

 

Pharmacology of Aminouracil Mustard

Uracil Mustard selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of Uracil Mustard-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed.

 

Additional information about Aminouracil Mustard

Aminouracil Mustard Indication: Used for its antineoplastic properties.
Mechanism Of Action: After activation, it binds preferentially to the guanine and cytosine moieties of DNA, leading to cross-linking of DNA, thus inhibiting DNA synthesis and function.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Uracil mustard
Synonyms: Not Available
Drug Category: Antineoplastic Agents
Drug Type: Small Molecule; Approved
Other Brand Names containing Uracil mustard: Aminouracil Mustard; Chlorethaminacil; Demethyldopan; Desmethyldopan; Haemanthamine; Nordopan; Uracil nitrogen mustard; Uracillost; Uracilmostaza; Uramustin; Uramustine;
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: 5%
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Aminouracil Mustard: Not Available
Chemical IUPAC Name: 5-[bis(2-chloroethyl)amino]-1H-pyrimidine-2,4-dione
Chemical Formula: C8H11Cl2N3O2
Uracil mustard on Wikipedia: http://en.wikipedia.org/wiki/Uracil_mustard
Organisms Affected: Humans and other mammals