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Amsine

Amsine - General Information

Aminoacridine derivative that is a potent intercalating antineoplastic agent. It is effective in the treatment of acute leukemias and malignant lymphomas, but has poor activity in the treatment of solid tumors. It is frequently used in combination with other antineoplastic agents in chemotherapy protocols. It produces consistent but acceptable myelosuppression and cardiotoxic effects.

 

Pharmacology of Amsine

Amsine is an aminoacridine derivative that is a potent intercalating antineoplastic agent. It is effective in the treatment of acute leukemias and malignant lymphomas, but has poor activity in the treatment of solid tumors. It is frequently used in combination with other antineoplastic agents in chemotherapy protocols. It produces consistent but acceptable myelosuppression and cardiotoxic effects.

 

Amsine for patients

 

Amsine Interactions

 

Amsine Contraindications

Avoid using with patients suffering bone marrow depression

 

Additional information about Amsine

Amsine Indication: For treatment of acute myeloid leukaemia.
Mechanism Of Action: Amsine binds to DNA through intercalation and external binding. It has a base specificity for A-T pairs. Rapidly dividing cells are two to four times more sensitive to amsacrine than are resting cells. Amsine appears to cleave DNA by inducing double stranded breaks. Amsine also targets and inhibits topoisomerase II. Cytotoxicity is greatest during the S phase of the cell cycle when topoisomerase levels are at a maximum.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Amsacrine
Synonyms: Acridinyl Anisidide; M-AMSA; MAMSA
Drug Category: Antineoplastic Agents
Drug Type: Small Molecule; Approved
Other Brand Names containing Amsacrine: Amsidine; Amsidyl; Amsine; AMSA P-D;
Absorption: Poorly absorbed
Toxicity (Overdose): Symptoms of overdose include nausea and vomiting, diarrhea, some cardiotoxicity (rarely).
Protein Binding: 96-98%
Biotransformation: Extensive, primarily hepatic, converted to glutathione conjugate.
Half Life: 8-9 hours
Dosage Forms of Amsine: Liquid Intravenous
Chemical IUPAC Name: N-[4-(acridin-9-ylamino)-3-methoxyphenyl]methanesulfonamide
Chemical Formula: C21H19N3O3S
Amsacrine on Wikipedia: http://en.wikipedia.org/wiki/Amsacrine
Organisms Affected: Humans and other mammals