Anectine - General Information
A quaternary skeletal muscle relaxant usually used in the form of its bromide, chloride, or iodide. It is a depolarizing relaxant, acting in about 30 seconds and with a duration of effect averaging three to five minutes. Anectine is used in surgical, anesthetic, and other procedures in which a brief period of muscle relaxation is called for.
Pharmacology of Anectine
Anectine is indicated as an adjunct to general anesthesia, to facilitate tracheal intubation, and to provide skeletal muscle relaxation during surgery or mechanical ventilation. Anectine is a depolarizing skeletal muscle relaxant. As does acetylcholine, it combines with the cholinergic receptors of the motor end plate to produce depolarization. This depolarization may be observed as fasciculations. Subsequent neuromuscular transmission is inhibited so long as adequate concentration of succinylcholine remains at the receptor site. Anectine has no direct action on the uterus or other smooth muscle structures.
Anectine for patients
Drugs which may enhance the neuromuscular blocking action of succinylcholine include: promazine, oxytocin, aprotinin, certain non-penicillin antibiotics, quinidine, b-adrenergic blockers, procainamide, lidocaine, trimethaphan, lithium carbonate, magnesium salts, quinine, chloroquine, diethylether, isoflurane, desflurane, metoclopramide, and terbutaline. The neuromuscular blocking effect of succinylcholine may be enhanced by drugs that reduce plasma cholinesterase activity (e.g., chronically administered oral contraceptives, glucocorticoids, or certain monoamine oxidase inhibitors) or by drugs that irreversibly inhibit plasma cholinesterase.
If other neuromuscular blocking agents are to be used during the same procedure, the possibility of a synergistic or antagonistic effect should be considered.
Succinylcholine is contraindicated in persons with personal or familial history of malignant hyperthermia, skeletal muscle myopathies, and known hypersensitivity to the drug. It is also contraindicated in patients after the acute phase of injury following major burns, multiple trauma, extensive denervation of skeletal muscle, or upper motor neuron injury, because succinylcholine administered to such individuals may result in severe hyperkalemia which may result in cardiac arrest. The risk of hyperkalemia in these patients increases over time and usually peaks at 7 to 10 days after the injury. The risk is dependent on the extent and location of the injury. The precise time of onset and the duration of the risk period are not known.
Additional information about Anectine
Anectine Indication: Used in surgical procedures where a rapid onset and brief duration of muscle relaxation is needed (includes intubation, endoscopies, and ECT)
Mechanism Of Action: The mechanism of action of Anectine involves what appears to be a "persistent" depolarization of the neuromuscular junction. This depolarization is caused by Anectine mimicking the effect of acetylcholine but without being rapidly hydrolysed by acetylcholinesterase. This depolarization leads to desensitization.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Succinylcholine
Synonyms: Succinylcholine Chloride; Suxamethonium chloride; Scoline
Drug Category: Neuromuscular Depolarizing Agents; Skeletal Muscle Relaxants
Drug Type: Small Molecule; Approved
Other Brand Names containing Succinylcholine: Anectine; Quelicin; Quelicin Preservative Free; Sucostrin;
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: By pseudocholinesterase, to succinylmonocholine and choline.
Half Life: Not Available
Dosage Forms of Anectine: Solution Intravenous
Chemical IUPAC Name: trimethyl-[2-[4-oxo-4-(2-trimethylazaniumylethoxy)butanoyl]oxyethyl]azanium
Chemical Formula: C14H30N2O4+2
Succinylcholine on Wikipedia: http://en.wikipedia.org/wiki/Succinylcholine
Organisms Affected: Humans and other mammals