Aniline Violet - General Information
A dye that is a mixture of violet rosanilinis with antibacterial, antifungal, and anthelmintic properties.
Pharmacology of Aniline Violet
Gentian violet is a mutagen, a mitotic poison, and a clastogen. Gentian violet has been used in medicine for almost 100 years: as an antiseptic for external use, as a topical antibiotic, as a topical antifungal agent, as an antihelminthic agent by oral administration, and more recently, as a blood additive to prevent transmission of Chagas' disease. It is thought to work by binding to the DNA of target organisms and causing disruption, mutation or inhibition of DNA replication.
Additional information about Aniline Violet
Aniline Violet Indication: For the treatment of bacterial and fungal infections inside the mouth (thrush) and skin, also for the prevention of transmission of Chagas' disease (as a blood additive).
Mechanism Of Action: In aqueous solutions Gentian violet (GV) dissociates into positive (GV+)and negative ions (Cl-) that penetrate through the wall and membrane of both gram-positive and gram-negative bacterial cells. The GV+ interacts with negatively charged components of bacterial cells including the lipopolysaccharide (on the cell wall), the peptidoglycan and DNA. A similar cell penetration and DNA binding process is thought to take place for fungal cells as well. Because Gentian violet is a mutagen and mitotic poison, cell growth is consequently inhibited. A photodynamic action of gentian violet, apparently mediated by a free-radical mechanism, has recently been described in bacteria and in the protozoan T. cruzi. Evidence also suggests that gentian violet dissipates the bacterial (and mitochondrial) membrane potential by inducing permeability. This is followed by respiratory inhibition. This anti-mitochondrial activity might explain gentian violet's efficacy towards both bacteria and yeast with relatively mild effects on mammalian cells.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Gentian Violet
Synonyms: Crystal Violet
Drug Category: Anti-Infective Agents, Local
Drug Type: Small Molecule; Approved
Other Brand Names containing Gentian Violet: Adergon; Aizen Crystal Violet; Aizen Crystal Violet Extra Pure; Aniline Violet; Aniline Violet pyoktanine; Atmonil; Avermin; Axuris; Badil; Basic Violet 3; Basic Violet BN; Basic Violet-3; Bismuth Violet; Brilliant Violet 5B; C.I. Basic Violet 3; Calcozine Violet 6BN; Calcozine Violet C; Crystal Violet 10B; Crystal Violet 5BO; Crystal Violet 6B; Crystal Violet 6BO; Crystal Violet AO; Crystal Violet AON; Crystal Violet BP; Crystal Violet BPC; Crystal Violet Extra Pure; Crystal Violet Extra Pure APN; Crystal Violet Extra Pure APNX; Crystal Violet FN; Crystal Violet HL2; Crystal Violet O; Crystal Violet Pure DSC; Crystal Violet Pure DSC Brilliant; Crystal Violet SS; Crystal Violet Technical; Crystal Violet USP; Crystal Violet base; Crystal Violet chloride; Crystal Violet chloride salt; GV-Eleven; Genapax; Gentersal; Gentiaverm; Genticid; Gentioletten; Gvs; Hecto Violet R; Hectograph Violet SR; Hexamethyl Violet; Hexamethylpararosaniline chloride; Hidaco Brilliant Crystal Violet; Hidaco crystal Violet; Meroxyl-Wander; Meroxylan-Wander; Methyl Violet 10B; Methyl Violet 10BD; Methyl Violet 10BK; Methyl Violet 10BN; Methyl Violet 10BNS; Methyl Violet 10BO; Methyl Violet 5BNO; Methyl Violet 5BO; Methyl Violet 6B; Methyl violet; Methylrosaniline chloride; Mitsui Crystal Violet; Oxiuran; Oxycolor; Oxyozyl; Paper Blue R; Plastoresin Violet 5BO; Pyoktanin; Vermicid; Vianin; Viocid; Violet 5BO; Violet 6BN; Violet CP; Violet XXIII; crystal violet for microscopy; gentian violet gr; gention violet alchoholic staining solution; methylrosanilinium chloride;
Absorption: Not Available
Toxicity (Overdose): LD50=420 mg/kg (rat, oral). Oral administration can cause gastrointestinal irritation, and intravenous injection can cause depression in the white blood cell count.
Protein Binding: Not Available
Biotransformation: Primarily hepatic, mostly demethylation
Half Life: Not Available
Dosage Forms of Aniline Violet: Liquid Topical
Chemical IUPAC Name: [4-[bis(4-dimethylaminophenyl)methylidene]-1-cyclohexa-2,5-dienylidene]-dimethylazanium
Chemical Formula: C25H30N3+
Gentian Violet on Wikipedia: http://en.wikipedia.org/wiki/Gentian_Violet
Organisms Affected: Yeast and other fungi; Bacteria and protozoa