Ansolysen - General Information
A nicotinic antagonist that has been used as a ganglionic blocking agent in hypertension.
Pharmacology of Ansolysen
Ansolysen acts as a ganglionic blocking agent. Ansolysen inhibits release of adrenaline and noradrenaline from adrenergic nerves. It is used as an antihypertensive, and can be administered orally, intramuscularly, and subcutaneously.
Additional information about Ansolysen
Ansolysen Indication: Used to produce controlled hypotension during surgical procedures and in hypertensive crises.
Mechanism Of Action: Ansolysen binds to the nicotinic (ganglion) acetylcholine receptor. This receptor/channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. Blockage of the receptor leads to smooth muscle relaxation and vasodilaton.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Pentolinium
Synonyms: Pentolinium tartrate; Pentolonium; Pentolonum
Drug Category: Antihypertensive Agents
Drug Type: Small Molecule; Approved
Other Brand Names containing Pentolinium: Ansolysen;
Absorption: Not Available
Toxicity (Overdose): Oral, mouse: LD50 = 512 mg/kg; Oral, rat: LD50 = 890 mg/kg.
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Ansolysen: Not Available
Chemical IUPAC Name: 1-methyl-1-[5-(1-methylpyrrolidin-1-ium-1-yl)pentyl]pyrrolidin-1-ium
Chemical Formula: C15H32N2+2
Pentolinium on Wikipedia: Not Available
Organisms Affected: Humans and other mammals