Antitrombosin - General Information
An oral anticoagulant that interferes with the metabolism of vitamin K. It is also used in biochemical experiments as an inhibitor of reductases.
Pharmacology of Antitrombosin
Antitrombosin is an coumarin-like compound found in sweet clover. It is used as an oral anticoagulant and acts by inhibiting the hepatic synthesis of vitamin K-dependent coagulation factors (prothrombin and factors VII, IX, and X). It is also used in biochemical experiments as an inhibitor of reductases.
Additional information about Antitrombosin
Antitrombosin Indication: For decreasing blood clotting
Mechanism Of Action: Antitrombosin inhibits vitamin K reductase, resulting in depletion of the reduced form of vitamin K (vitamin KH2). As vitamin K is a cofactor for the carboxylation of glutamate residues on the N-terminal regions of vitamin K-dependent proteins, this limits the gamma-carboxylation and subsequent activation of the vitamin K-dependent coagulant proteins. The synthesis of vitamin K-dependent coagulation factors II, VII, IX, and X and anticoagulant proteins C and S is inhibited. Depression of three of the four vitamin K-dependent coagulation factors (factors II, VII, and X) results in decresed prothrombin levels and a decrease in the amount of thrombin generated and bound to fibrin. This reduces the thrombogenicity of clots.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Dicumarol
Synonyms: Dicoumarol; Bis-Hydroxycoumarin; BHC; Bishydroxycoumarin; Dicoumarin
Drug Category: Uncoupling Agents; Anticoagulants; Enzyme Inhibitors
Drug Type: Small Molecule; Approved
Other Brand Names containing Dicumarol: Acadyl; Acavyl; Antitrombosin; Baracoumin; Cuma; Cumid; Dicoumal; Dicuman; Dicumaol R; Dicumarine; Dicumol; Dikumarol; Dufalone; Kumoran; Melitoxin; Temparin; Trombosan;
Absorption: Not Available
Toxicity (Overdose): LD50=233 mg/kg (orally in mice); LD50=250 mg/kg (orally in rats)
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Antitrombosin: Tablet Oral
Chemical IUPAC Name: 2-hydroxy-3-[(2-hydroxy-4-oxochromen-3-yl)methyl]chromen-4-one
Chemical Formula: C19H12O6
Dicumarol on Wikipedia: http://en.wikipedia.org/wiki/Dicumarol
Organisms Affected: Humans and other mammals