Aphthasol - General Information

Aphthasol is an antiallergic drug, clinically effective for atopic diseases, especially allergic asthma and rhinitis. Aphthasol as a topical paste is a well tolerated treatment of recurrent aphthous ulcers. Recurrent aphthous ulcer (RAU) is the most prevalent oral mucosal disease in humans, estimated to affect between 5% and 50% of the general population.


Pharmacology of Aphthasol

Aphthasol is a mucoadhesive oral paste which has been clinically proven to abort the onset, accelerate healing and resolve the pain of aphthous ulcers (canker sores). It decreases the time ulcers take to heal. Because amlexanox decreases the healing time, it also decreases the pain you feel. Recent studies have also shown that the majority of ulcers can be prevented by application of the paste during the prodromal (pre-ulcerative) phase of the disease. Recurrent Aphthous Ulcers (RAU) also known as Recurrent Aphthous Stomatitis (RAS) is recognized as the most common oral mucosal disease known to man. Estimates suggest that 20% - 25% of the general population suffer at least one incidence of aphthous ulcers each year.


Aphthasol for patients

This medication is only for treatment of mouth ulcers; do not apply to ulcers of the eye or any other part of the body. Use as directed. Apply after eating. Wash hands before and after use. Brush teeth and rinse mouth before applying directly to ulcers. Squeeze a small amount of paste on your clean finger tip and dab paste onto each ulcer in the mouth, using gentle pressure. Wash eyes immediately if any paste should come into contact with eyes. Notify prescriber or dentist if rash or irritation occurs, or if condition does not improve after 10 days use. Breast-feeding precaution: Consult prescriber if breast-feeding.


Aphthasol Interactions


Aphthasol Contraindications

Hypersensitivity to amlexanox or any component of the formulation.


Additional information about Aphthasol

Aphthasol Indication: Used as a paste in the mouth to treat aphthous ulcers (canker sores).
Mechanism Of Action: As a benzopyrano-bipyridine carboxylic acid derivative, amlexanox has anti-inflammatory and antiallergic properties. It inhibits chemical mediatory release of the slow-reacting substance of anaphylaxis (SRS-A) and may have antagonistic effects on interleukin-3.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Amlexanox
Synonyms: Amlexanox [USAN-INN-JAN]; Amlexanoxo [Spanish]; Amlexanoxum [Latin]
Drug Category: Anti-Allergic Agents; Antiulcer agent (topical); Anti-inflammatory, Locally Applied
Drug Type: Small Molecule; Approved; Investigational
Other Brand Names containing Amlexanox: Amlenanox; Amoxanox; Aphthasol; Elics; Solfa;
Absorption: No significant absorption directly through the active ulcer. Most of the systemic absorption is via the gastrointestinal tract.
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Metabolized to hydroxylated and conjugated metabolites.
Half Life: Elimination half-life is 3.5 ± 1.1 hours.
Dosage Forms of Aphthasol: Not Available
Chemical IUPAC Name: 2-amino-5-oxo-7-propan-2-ylchromeno[3,2-e]pyridine-3-carboxylic acid
Chemical Formula: C16H14N2O4
Amlexanox on Wikipedia: Not Available
Organisms Affected: Humans and other mammals