Apl-Luster - General Information
2-Substituted benzimidazole first introduced in 1962. It is active against a variety of nematodes and is the drug of choice for strongyloidiasis. It has CNS side effects and hepatototoxic potential. (From Smith and Reynard, Textbook of Pharmacology, 1992, p919)
Pharmacology of Apl-Luster
Apl-Luster is a fungicide and parasiticide. Apl-Luster is also a chelating agent, which means that it is used medicinally to bind metals in cases of metal poisoning, such as lead poisoning, mercury poisoning or antimony poisoning. Apl-Luster is vermicidal and/or vermifugal against Ascaris lumbricoides ("common roundworm"), Strongyloides stercoralis (threadworm), Necator americanus, Ancylostoma duodenale (hookworm), Trichuris trichiura (whipworm), Ancylostoma braziliense (dog and cat hookworm), Toxocara canis, Toxocara cati (ascarids), and Enterobius vermicularis (pinworm). Apl-Luster also suppresses egg and/or larval production and may inhibit the subsequent development of those eggs or larvae which are passed in the feces.
Apl-Luster for patients
Because CNS side effects may occur quite frequently, activities requiring mental alertness should be avoided.
Thiabendazole may compete with other drugs, such as theophylline, for sites of metabolism in the liver, thus elevating the serum levels of such compounds to potentially toxic levels. Therefore, when concomitant use of thiabendazole and xanthine derivatives is anticipated, it may be necessary to monitor blood levels and/or reduce the dosage of such compounds. Such concomitant use should be administered under careful medical supervision.
Hypersensitivity to this product.
Thiabendazole is contraindicated as prophylactic treatment for pinworm infestation.
Additional information about Apl-Luster
Apl-Luster Indication: For the treatment of strongyloidiasis (threadworm), cutaneous larva migrans (creeping eruption), visceral larva migrans, and trichinosis.
Mechanism Of Action: The precise mode of action of thiabendazole on the parasite is unknown, but it most likely inhibits the helminth-specific enzyme fumarate reductase.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Thiabendazole
Synonyms: TBDZ; TBZ; Thiabendazol; Thiabendole; Thiabenzazole; Thiabenzole; Tiabendazol; Tiabendazole
Drug Category: Antinematodal Agents
Drug Type: Small Molecule; Approved
Other Brand Names containing Thiabendazole: Apl-Luster; Arbotect; Bioguard; Bovizole; Chemviron TK 100; Cropasal; Drawipas; Eprofil; Equivet TZ; Equizole; Hokustar hp; Hymush; Lombristop; Mertec; Mertect; Mertect 160; Mertect 340f; Mertect lsp; Metasol TK 100; Metasol TK 10; Mintesol; Mintezol; Minzolum; Mycozol; Nemacin; Nemapan; Omnizole; Ormogal; Polival; RPH; Sanaizol 100; Sistesan; Storite; TBZ 6; TBZ 60W; Tebuzate; Tecto; Tecto 10P; Tecto 40F; Tecto 60; Tecto B; Tecto rph; Testo; Thiaben; Thibendole; Thibenzol; Thibenzole; Thibenzole 200; Thibenzole att; Thiprazole; Tiabenda; Tibimix 20; Tobaz; Top form wormer; Triasox; Tubazole;
Absorption: Rapidly absorbed and peak plasma concentration is reached within 1 to 2 hours after the oral administration of a suspension. Some systemic absorption may occur from topical preparations applied to the skin.
Toxicity (Overdose): Overdosage may be associated with transient disturbances of vision and psychic alterations. The oral LD 50 is 3.6 g/kg, 3.1 g/kg and 3.8 g/kg in the mouse, rat, and rabbit respectively.
Protein Binding: Not Available
Biotransformation: Hepatic. Metabolized almost completely to the 5-hydroxy form which appears in the urine as glucuronide or sulfate conjugates.
Half Life: The half-life for thiabendazole in both normal and anephric patients is 1.2 hours (range 0.9 to 2 hours). The half-life for the 5-hydroxythiabendazole metabolite in both normal and anephric patients is 1.7 hours (range 1.4 to 2 hours).
Dosage Forms of Apl-Luster: Tablet, chewable Oral
Chemical IUPAC Name: 2-(1,3-thiazol-4-yl)-1H-benzimidazole
Chemical Formula: C10H7N3S
Thiabendazole on Wikipedia: http://en.wikipedia.org/wiki/Thiabendazole
Organisms Affected: Roundworms, hookworms, and other helminth species