Apo-Indapamide - General Information
A benzamide-sulfonamide-indole. It is called a thiazide-like diuretic but structure is different enough (lacking the thiazo-ring) so it is not clear that the mechanism is comparable.
Pharmacology of Apo-Indapamide
Apo-Indapamide is an antihypertensive and a diuretic. It contains both a polar sulfamoyl chlorobenzamide moiety and a lipid- soluble methylindoline moiety. Apo-Indapamide bears a structural similarity to the triazide diuretics which are known to decrease vascular smooth muscle reactivity. However, it differs chemically from the thiazides in that it does not possess the thiazide ring system and contains only one sulfonamide group. Apo-Indapamide appears to cause vasodilation, probably by inhibiting the passage of calcium and other ions (sodium, potassium) across membranes. This same effect may cause hypokalcemia in susceptible individuals. Apo-Indapamide has also been shown to cause uterine myometrial relaxation in experimental animals. Overall, indapamide has an extra-renal antihypertensive action resulting in a decrease in vascular hyperreactivity and a reduction in total peripheral and arteriolar resistance.
Apo-Indapamide for patients
Anuria. Known hypersensitivity to indapamide or to other sulfonamide-derived drugs.
Additional information about Apo-Indapamide
Apo-Indapamide Indication: For the treatment of hypertension, alone or in combination with other antihypertensive drugs as well as for the treatment of salt and fluid retention associated with congestive heart failure or edema from pregnancy.
Mechanism Of Action: Apo-Indapamide blocks the slow component of delayed rectifier potassium current (IKs) without altering the rapid component (IKr) or the inward rectifier current. Specifically it blocks or antagonizes the action the proteins KCNQ1 and KCNE1. Apo-Indapamide is also thought to stimulate the synthesis of the vasodilatory hypotensive prostaglandin PGE2.
Drug Interactions: Amantadine The diuretic increases the adverse effect of amantadine
Deslanoside Possible electrolyte variations and arrhythmias
Diazoxide Significant hyperglycemic effect
Digitoxin Possible electrolyte variations and arrhythmias
Digoxin Possible electrolyte variations and arrhythmias
Dofetilide Increased risk of cardiotoxicity and arrhythmias
Lithium The thiazide diuretic increases serum levels of lithium
Food Interactions: Take without regard to meals. Magnesium, potassium and zinc needs increased.
Generic Name: Indapamide
Synonyms: Indapamida [INN-Spanish]; Indapamidum [INN-Latin]
Drug Category: Antihypertensive Agents; Diuretics
Drug Type: Small Molecule; Approved
Other Brand Names containing Indapamide: Apo-Indapamide; Arifon; Bajaten; Cormil; Damide; Fludex; Gen-Indapamide; Idapamide; Indaflex; Indamol; Ipamix; Lozide; Lozol; Natrilix; Natrix; Noranat; Novo-Indapamide; Nu-Indapamide; Pressurai; Tandix; Tertensif; Veroxil;
Absorption: Rapidly absorbed from gastrointestinal tract.
Toxicity (Overdose): Side effects include electrolyte imbalance (potassium or salt depletion due to too much fluid loss), nausea, stomach disorders, vomiting, weakness
Protein Binding: 71-79%
Biotransformation: Primarily hepatic. Indapamide is an extensively metabolized drug with only about 7+ACU- of the total dose administered, recovered in the urine as unchanged drug during the first 48 hours after administration.
Half Life: 14 hours (biphasic)
Dosage Forms of Apo-Indapamide: Tablet Oral
Chemical IUPAC Name: 4-chloro-N-(2-methyl-2,3-dihydroindol-1-yl)-3-sulfamoylbenzamide
Chemical Formula: C16H16ClN3O3S
Indapamide on Wikipedia: http://en.wikipedia.org/wiki/Indapamide
Organisms Affected: Humans and other mammals