Apodol - General Information
Apodol is a synthetic opioid and strong analgesic medication. It is a narcotic pain reliever used to treat moderate to severe pain. Narcotic analgesics act in the central nervous system (CNS) to relieve pain. Some of their side effects are also caused by actions in the CNS.
Pharmacology of Apodol
Apodol, a potent analgesic, is an analog of pethidine. Apodol is useful for the relief of moderate to severe pain. It may also be used as an analgesic adjunct in general anesthesia in the same manner as meperidine to reduce the amount of anesthetic needed, to facilitate relaxation, and to reduce laryngospasm. In addition, anileridine exerts mild antihistaminic, spasmolytic and antitussive effects. Apodol's main pharmacologic action is exerted on the CNS. Respiratory depression, when it occurs, is of shorter duration than that seen with morphine or meperidine when equipotent analgesic doses are used.
Apodol for patients
Caution should be observed when anileridine is coadministered with other opioids, sedatives, phenothiazines, or anesthetics, as these agents may increase respiratory and circulatory depression.
Anileridine is contraindicated in the presence of respiratory depression. It should not be used when respiratory failure is a possibility (head injury or brain tumor). In addition, the use of anileridine is contraindicated when there is a known hypersensitivity to the drug or any of the nonmedicinal ingredients of the preparations.
Additional information about Apodol
Apodol Indication: For treatment and management of pain (systemic) and for use as an anesthesia adjunct.
Mechanism Of Action: Opiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline is inhibited. Opioids also inhibit the release of vasopressin, somatostatin, insulin and glucagon. Opioids such as anileridine close N-type voltage-operated calcium channels (OP2-receptor agonist) and open calcium-dependent inwardly rectifying potassium channels (OP3 and OP1 receptor agonist). This results in hyperpolarization and reduced neuronal excitability.
Drug Interactions: Not Available
Food Interactions: Take without regard to meals.
Generic Name: Anileridine
Synonyms: Anileridina [Inn-Spanish]; Anileridinum [Inn-Latin]; Phthalylsulfathiazole; Sulfathalidine
Drug Category: Analgesics; Narcotics; Opiate Agonists
Drug Type: Small Molecule; Illicit; Approved
Other Brand Names containing Anileridine: Adopol; Alidine; Apidol; Apodol; Leritin; Leritine; Nipecotan;
Absorption: Anileridine is absorbed by all routes of administration.
Toxicity (Overdose): Symptoms of overexposure include dizziness, perspiration, a feeling of warmth, dry mouth, visual difficulty, itching, euphoria, restlessness, nervousness and excitement have been reported.
Protein Binding: > 95%
Half Life: Not Available
Dosage Forms of Apodol: Not Available
Chemical IUPAC Name: ethyl 1-[2-(4-aminophenyl)ethyl]-4-phenylpiperidine-4-carboxylate
Chemical Formula: C22H28N2O2
Anileridine on Wikipedia: http://en.wikipedia.org/wiki/Anileridine
Organisms Affected: Humans and other mammals