Aquamox - General Information
Aquamox (INN, brand name Hydromox) is a thiazide diuretic used to treat hypertension. Common side effects include dizziness, dry mouth, nausea, and low potassium levels.
Pharmacology of Aquamox
Aquamox is a thiazide diuretic used to treat hypertension. It inhibits Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue.
Additional information about Aquamox
Aquamox Indication: Used to treat hypertension.
Mechanism Of Action: As a diuretic, quinethazone inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water. Thiazides like quinethazone also inhibit sodium ion transport across the renal tubular epithelium through binding to the thiazide sensitive sodium-chloride transporter. This results in an increase in potassium excretion via the sodium-potassium exchange mechanism. The antihypertensive mechanism of quinethazone is less well understood although it may be mediated through its action on carbonic anhydrases in the smooth muscle or through its action on the large-conductance calcium-activated potassium (KCa) channel, also found in the smooth muscle.
Drug Interactions: Not Available
Food Interactions: Take with food to increase bioavailability.
Generic Name: Quinethazone
Synonyms: Chinetazone [dcit]; Chinethazonum; Quinetazona [inn-spanish]; Quinethazon; Quinethazonum [inn-latin]
Drug Category: Antihypertensive Agents; Diuretics, Thiazide
Drug Type: Small Molecule; Approved
Other Brand Names containing Quinethazone: Aquamox; Hydromox; Idrokin;
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Aquamox: Tablet Oral
Chemical IUPAC Name: 7-chloro-2-ethyl-4-oxo-2,3-dihydro-1H-quinazoline-6-sulfonamide
Chemical Formula: C10H12ClN3O3S
Quinethazone on Wikipedia: http://en.wikipedia.org/wiki/Quinethazone
Organisms Affected: Humans and other mammals