Arfonad - General Information
A nicotinic antagonist that has been used as a ganglionic blocker in hypertension, as an adjunct to anesthesia, and to induce hypotension during surgery.
Pharmacology of Arfonad
Arfonad is indicated for production of controlled hypotension during surgery to reduce bleeding into the surgical field and also for rapid reduction of blood pressure in the treatment of hypertensive emergencies, especially in patients with acute dissecting aneurysm, and in the emergency treatment of pulmonary edema in patients with pulmonary hypertension associated with systemic hypertension.
Additional information about Arfonad
Arfonad Indication: For the controlled reduction of blood pressure during surgery and in the treatment of hypertensive emergencies.
Mechanism Of Action: Arfonad is a ganglionic blocking agent prevents stimulation of postsynaptic receptors by competing with acetylcholine for these receptor sites. Additional effects may include direct peripheral vasodilation and release of histamine. Arfonad's hypotensive effect is due to reduction in sympathetic tone and vasodilation, and is primarily postural.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Trimethaphan
Synonyms: Thimethaphan; Trimetaphan; Trimetaphanum
Drug Category: Antihypertensive Agents; Vasodilator Agents
Drug Type: Small Molecule; Approved
Other Brand Names containing Trimethaphan: Arfonad;
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Arfonad: Not Available
Chemical IUPAC Name: 1,1,2,2,2-pentadeuterioethanamine
Chemical Formula: C22H25N2OS+
Trimethaphan on Wikipedia: http://en.wikipedia.org/wiki/Trimethaphan
Organisms Affected: Humans and other mammals