Arpicolin - General Information
A muscarinic antagonist that crosses the blood-brain barrier and is used in the treatment of drug-induced extrapyramidal disorders and in parkinsonism.
Pharmacology of Arpicolin
Arpicolin has an atropine-like action. It's antispasmodic effects are thought to be related to the blockage of central cholinergic receptors M1, M2 and M4. It is used to treat symptomatic Parkinsonism and extrapyramidal dysfunction caused by antipsychotic agents.
Arpicolin for patients
Follow your doctors instructions for taking this medicine. This medicine can be taken with food or a snack,
to minimize stomach upset. As your body becomes used to the medicine, it should be taken on an empty
stomach. Talk to your doctor about the best time of day to take the medicine. For patients taking the
extended-release forms, swallow the tablet whole, do NOT CRUSH or CHEW. You may break the tablet in half
if the whole pill is too large for you to take.
This medicine can cause dizziness or drowsiness. Be cautious when driving or performing other hazardous
activities. This medicine can impair judgment. Do NOT increase your dose of this medicine without first
talking to your doctor, even if you feel that the medicine is not working.
Discuss the risks and benefits of using this medicine during pregnancy. It is unknown whether this medicine
is excreted in breast milk. DO NOT breastfeed while taking this medicine until you have talked to your
doctor or pediatrician.
Procyclidine can interact with the follwing drugs:
amantadine or rimantadine, narcotic analgesics, amitriptyline (Elavil, Endep), doxepin (Sinequan), or
clomipramine (Anafranil), quinidine (Quinora, Quinaglute, Quinidex, Cardioquin), some antiarrhythmics,
antihistamines (diphenhydramine, chlorpheniramine, triprolidine, brompheniramine, clemastine, etc),
Atenolol, Cholinergic agents (tacrine and donepezil), Digoxin, Levodopa, phenothiazines, chlorpromazine
(Thorazine), fluphenazine (Prolixin), perphenazine (Trilafon), mesoridazine (Serentil), thioridazine
(Mellaril), promazine (Sparine), trifluoperazine, and haloperidol.
Drugs other than listed here may also have interactions with Procyclidine.
Procyclidin should not be given to patients with angle-closure glaucoma.
Additional information about Arpicolin
Arpicolin Indication: For the treatment of Parkinson's Disease (especially drug induced)
Mechanism Of Action: The mechanism of action is unknown. It is thought that Arpicolin acts by blocking central cholinergic receptors, and thus balancing cholinergic and dopaminergic activity in the basal ganglia. Many of its effects are due to its pharmacologic similarities with atropine.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Procyclidine
Synonyms: Prociclidina [Inn-Spanish]; Procyclidinum [Inn-Latin]
Drug Category: Antiparkinson Agents; Antidyskinetics; Muscarinic Antagonists
Drug Type: Small Molecule; Approved
Other Brand Names containing Procyclidine: Arpicolin; Elorine; Kemadrin; Kemadrine; Lergine; Metanin; Osnervan; Procyclid; Procyklidin; Prosyklidin; Spamol; Triciclidina; Triciloid; Tricoloid; Tricyclamol; Vagosin;
Absorption: Not Available
Toxicity (Overdose): LD50=60 mg/kg (IV in mice)
Protein Binding: Approximately 100% bound to albumin.
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Arpicolin: Tablet Oral
Chemical IUPAC Name: 1-cyclohexyl-1-phenyl-3-pyrrolidin-1-ylpropan-1-ol
Chemical Formula: C19H29NO
Procyclidine on Wikipedia: http://en.wikipedia.org/wiki/Procyclidine
Organisms Affected: Humans and other mammals