Averon-1 - General Information

A cephalosporin antibiotic.


Pharmacology of Averon-1

Averon-1 (INN) or cephalothin (USAN) is a semisynthetic first generation cephalosporin having a broad spectrum of antibiotic activity that is administered parenterally.


Additional information about Averon-1

Averon-1 Indication: Used to prevent infection during surgery and to treat many kinds of infections of the blood, bone or joints, respiratory tract, skin, and urinary tract.
Mechanism Of Action: The bactericidal activity of cefalotin results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs).
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Cefalotin
Synonyms: Cefalotina [INN-Spanish]; Cefalotine [INN-French]; Cefalotinum [INN-Latin]; Cephalothin Sodium; Cephalothinum; Cephalothin; Cephalotin; CLS; Cefalothin
Drug Category: Anti-Bacterial Agents
Drug Type: Small Molecule; Approved
Other Brand Names containing Cefalotin: Averon-1; Cemastin; Coaxin; Keflin; Seffin;
Absorption: Not Available
Toxicity (Overdose): Rat intravenous LD50 is 4000 mg/kg.
Protein Binding: 65-80%
Biotransformation: Metabolized to a less active desacetyl metabolite, although 50-75% of the drug is eliminated unchanged in the urine.
Half Life: 30 minutes
Dosage Forms of Averon-1: Powder, for solution Intravenous
Chemical IUPAC Name: (6R,7R)-3-(acetyloxymethyl)-8-oxo-7-[(2-thiophen-2-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Chemical Formula: C16H16N2O6S2
Cefalotin on Wikipedia:
Organisms Affected: Enteric bacteria and other eubacteria