Azlin - General Information
A semisynthetic ampicillin-derived acylureido penicillin.
Pharmacology of Azlin
Azlin, similar to mezlocillin and piperacillin, is an acylampicillin with an extended spectrum of activity and greater in vitro potency than the carboxy penicillins. Azlin demonstrates antibacterial activity against a broad spectrum of bacteria, including Pseudomonas aeruginosa, and, in contrast to most cephalosporins, exhibits activity against enterococci.
Azlin for patients
Azlocillin should not be administered concomitantly with amikacin, ciprofloxacin, gentamicin, netilmicin, or tobramycin.
Contraindicated in penicillin hypersensitivity.
Additional information about Azlin
Azlin Indication: For the treatment of infections caused by Pseudomonas aeruginosa, Escherichia coli, and Haemophilus influenzae.
Mechanism Of Action: By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, azlocillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that azlocillin interferes with an autolysin inhibitor.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Azlocillin
Synonyms: Azlocilina [INN-Spanish]; Azlocillin sodium salt; Azlocilline [INN-French]; Azlocillinum [INN-Latin]
Drug Category: Anti-Bacterial Agents; Penicillins
Drug Type: Small Molecule; Approved
Other Brand Names containing Azlocillin: Azlin; Bayer Brand of Azlocillin; Securopen;
Absorption: Not significantly absorbed from the gastrointestinal tract.
Toxicity (Overdose): Not Available
Protein Binding: 20 to 46% bound to plasma proteins
Biotransformation: Eliminated predominantly by renal mechanisms, but also undergoes biotransformation within body tissues and intraintestinal degradation by bowel bacteria, with high concentrations found in bile.
Half Life: Mean elimination half-life is 1.3 to 1.5 hours. Longer in neonates, and 2 to 6 hours in patients with renal impairment.
Dosage Forms of Azlin: Not Available
Chemical IUPAC Name: (2S,5R,6R)-3,3-dimethyl-7-oxo-6-[[2-[(2-oxoimidazolidine-1-carbonyl)amino]-2-phenylacetyl]amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Chemical Formula: C20H23N5O6S
Azlocillin on Wikipedia: http://en.wikipedia.org/wiki/Azlocillin
Organisms Affected: Enteric bacteria and other eubacteria