Bactocill - General Information

An antibiotic similar to flucloxacillin used in resistant staphylococci infections.


Pharmacology of Bactocill

Bactocill is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name "penicillin" can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Bactocill has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of Bactocill results from the inhibition of cell wall synthesis and is mediated through Bactocill binding to penicillin binding proteins (PBPs). Bactocill is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases.


Bactocill for patients


Bactocill Interactions

Tetracycline, a bacteriostatic antibiotic, may antagonize the bactericidal effect of penicillin and concurrent use of these drugs should be avoided.


Bactocill Contraindications

A history of a hypersensitivity (anaphylactic) reaction to any penicillin is a contraindication.


Additional information about Bactocill

Bactocill Indication: Used in the treatment of resistant staphylococci infections.
Mechanism Of Action: By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, Bactocill inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that Bactocill interferes with an autolysin inhibitor.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Oxacillin
Synonyms: Oxacillin Sodium
Drug Category: Anti-Bacterial Agents; Penicillins
Drug Type: Small Molecule; Approved
Other Brand Names containing Oxacillin: Bactocill;
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: 94.2 +/- 2.1% (binds to serum protein, mainly albumin)
Biotransformation: Not Available
Half Life: 20 to 30 minutes
Dosage Forms of Bactocill: Solution Intramuscular
Injection, solution Intravenous bolus
Injection, solution Intravenous drip
Capsule Oral
Chemical IUPAC Name: (2S,5R,6R)-3,3-dimethyl-6-[(5-methyl-3-phenyl1,2-oxazole-4-carbonyl)amino]-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Chemical Formula: C19H19N3O5S
Oxacillin on Wikipedia:
Organisms Affected: Enteric bacteria and other eubacteria