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Bambec

Bambec - General Information

Bambec is a long acting beta-adrenoceptor agonist used in the treatment of asthma. It is a prodrug of terbutaline.

 

Pharmacology of Bambec

Bambec is a long acting beta2-adrenoceptor agonist used in the treatment of asthma. It is a prodrug of terbutaline.

 

Additional information about Bambec

Bambec Indication: For the prevention and reversal of bronchospasm in patients 12 years of age and older with asthma and reversible bronchospasm associated with bronchitis and emphysema.
Mechanism Of Action: The pharmacologic effects of bambuterol are at least in part attributable to stimulation through beta-adrenergic receptors of intracellular adenyl cyclase, the enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic AMP. Increased cyclic AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Bambuterol
Synonyms: Bambuterol hydrochloride
Drug Category: Bronchodilator Agents; Adrenergic beta-Agonists; Tocolytic Agents; Sympathomimetics
Drug Type: Small Molecule; Approved
Other Brand Names containing Bambuterol: Bambec; Oxeol;
Absorption: Bioavailability is 20% following oral administration.
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Hepatic, extensive. Further metabolized to terbutaline by plasma cholinesterase.
Half Life: 13 hours for bambuterol and 21 hours for the primary active metabolite terbutaline.
Dosage Forms of Bambec: Tablet Oral
Chemical IUPAC Name: [3-[2-(tert-butylamino)-1-hydroxyethyl]-5-(dimethylcarbamoyloxy)phenyl] N,N-dimethylcarbamate
Chemical Formula: C18H29N3O5
Bambuterol on Wikipedia: http://en.wikipedia.org/wiki/Bambuterol
Organisms Affected: Humans and other mammals