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Barstatin 100

Barstatin 100 - General Information

Barstatin 100 is a polyene antifungal drug to which many molds and yeasts are sensitive, including Candida spp. Barstatin 100 has some toxicity associated with it when given intravenously, but it is not absorbed across intact skin or mucous membranes. It is considered a relatively safe drug for treating oral or gastrointestinal fungal infections.

 

Pharmacology of Barstatin 100

Barstatin 100 is an antibiotic which is both fungistatic and fungicidal in vitro against a wide variety of yeasts and yeast-like fungi, including Candida albicans, C. parapsilosis, C. tropicalis, C. guilliermondi, C. pseudotropicalis, C. krusei, Torulopsis glabrata, Tricophyton rubrum, T. mentagrophytes. Barstatin 100 acts by binding to sterols in the cell membrane of susceptible species resulting in a change in membrane permeability and the subsequent leakage of intracellular components. On repeated subculturing with increasing levels of nystatin, Candida albicans does not develop resistance to nystatin. Generally, resistance to nystatin does not develop during therapy. However, other species of Candida (C. tropicalis, C. guilliermondi, C. krusei, and C. stellatoides) become quite resistant on treatment with nystatin and simultaneously become cross resistant to amphotericin as well. This resistance is lost when the antibiotic is removed. Barstatin 100 exhibits no appreciable activity against bacteria, protozoa, or viruses.

 

Barstatin 100 for patients

 

Barstatin 100 Interactions

 

Barstatin 100 Contraindications

Nystatin Topical Powder is contraindicated in patients with a history of hypersensitivity to any of its components.

 

Additional information about Barstatin 100

Barstatin 100 Indication: For treatment of cutaneous or mucocutaneous mycotic infections caused by Candida species
Mechanism Of Action: Barstatin 100 interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary for the conversion of lanosterol to ergosterol. This results in inhibition of ergosterol synthesis and increased fungal cellular permeability.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Nystatin
Synonyms: Not Available
Drug Category: Anti-Bacterial Agents; Antifungal Agents; Ionophores
Drug Type: Small Molecule; Approved
Other Brand Names containing Nystatin: Barstatin 100; Candex; Korostatin; Myco-Triacet Ii; Mycolog-Ii; Mycostatin; Mykacet; Mykinac; Mytrex F; Nadostine; Nilstat; Nyaderm; Nysert; Nystaform; Nystatin sodium; Nystatin, sodium salt; Nystatin-Triamcinolone Acetonide; Nystex; Nystop; PMS Nystatin; Pedi-Dri; Sodium nystatin; nystatin dihydrate;
Absorption: Nystatin is not absorbed from intact skin or mucous membrane
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Barstatin 100: Tablet Oral
Ointment Topical
Tablet Intravaginal
Suspension Oral
Cream Intravaginal
Solution / drops Oral
Cream Topical
Powder Topical
Chemical IUPAC Name: (21E,23E,25E,27E,31E,33E)-20-[(3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-4,6,8,11,12,16,18,36-octahydroxy-35,37,38-trimethyl-2,14-dioxo-1-oxacyclooctatriaconta-21,23,25,27,31,33-hexaene-17-carboxylic acid
Chemical Formula: C47H75NO17
Nystatin on Wikipedia: http://en.wikipedia.org/wiki/Nystatin
Organisms Affected: Fungi