Bellasthman - General Information
Isopropyl analog of epinephrine; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant.
Pharmacology of Bellasthman
Bellasthman is a relatively selective beta2-adrenergic bronchodilator. Bellasthman is indicated for the relief of bronchospasm associated with chronic obstructive pulmonary disease. The pharmacologic effects of beta adrenergic agonist drugs, including Bellasthman, are at least in part attributable to stimulation through beta adrenergic receptors of intracellular adenyl cyclase, the enzyme which catalyzes the conversion of adenosine triphosphate (ATP) to cyclic- 3',5'- adenosine monophosphate (c-AMP). Increased c-AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells.
Bellasthman for patients
Isoproterenol hydrochloride injection and epinephrine should not be administered simultaneously because both drugs are direct cardiac stimulants and their combined effects may induce serious arrhythmias. The drugs may, however, be administered alternately provided a proper interval has elapsed between doses.
ISUPREL should be used with caution, if at all, when potent inhalational anesthetics such as halothane are employed because of potential to sensitize the myocardium to effects of sympathomimetic amines.
Use of isoproterenol hydrochloride injection is contraindicated in patients with tachyarrhythmias; tachycardia or heart block caused by digitalis intoxication; ventricular arrhythmias which require inotropic therapy; and angina pectoris.
Additional information about Bellasthman
Bellasthman Indication: For the treatment of mild or transient episodes of heart block that do not require electric shock or pacemaker therapy also used in management of asthma and chronic bronchitis
Mechanism Of Action: The pharmacologic effects of isoproterenol are at least in part attributable to stimulation through beta-adrenergic receptors of intracellular adenyl cyclase, the enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic AMP. Increased cyclic AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Isoproterenol
Synonyms: IPA; Epinephrine Isopropyl Homolog; Isopropyladrenaline; Isopropylarterenol; Isopropylnoradrenaline; Isopropylnorepinephrine; Isoproterenol Chloride; Isoproterenol HCl; L-Isopropylnoradrenaline; L-Isoproterenol; N-Isopropylnoradrenaline; N-Isopropylnorepinephrine; Isopropydrin; Isoprenalin; Isoprenaline
Drug Category: Cardiotonic Agents; Bronchodilator Agents; Sympathomimetic
Drug Type: Small Molecule; Approved
Other Brand Names containing Isoproterenol: Aerolone; Aleudrin; Aleudrine; Aludrin; Aludrine; Asiprenol; Asmalar; Assiprenol; Bellasthman; Bronkephrine; Euspiran; Isadrine; Isonorene; Isonorin; Isorenin; Isuprel; Isuprel Mistometer; Isupren; Medihaler-Iso; Neo-Epinine; Neodrenal; Norisodrine; Norisodrine Aerotrol; Novodrin; Proternol; Respifral; Saventrine; Vapo-Iso;
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Bellasthman: Liquid Topical
Liquid Auricular (otic)
Chemical IUPAC Name: 4-[1-hydroxy-2-(propan-2-ylamino)ethyl]benzene-1,2-diol
Chemical Formula: C11H17NO3
Isoproterenol on Wikipedia: http://en.wikipedia.org/wiki/Isoproterenol
Organisms Affected: Humans and other mammals