Benefix (Genetics Institute) - General Information
Human Factor IX protein, produced by recombinant DNA technology for use in therapy of factor IX deficiency, known as hemophilia B or Christmas disease. Benefix (Genetics Institute) (Recombinant) is a glycoprotein with an approximate molecular mass of 55,000 Da consisting of 415 amino acids in a single chain. It has a primary amino acid sequence that is identical to the Ala 148 allelic form of plasma-derived factor IX.
Pharmacology of Benefix (Genetics Institute)
Binds vitamin K and factor VIIIa. Cleaves the Arg-Ile bond in factor X to form active factor Xa. Plays a key role in blood coagulation and clotting. Injections of factor IX are used to treat hemophilia B, which is sometimes called Christmas disease. AlphaNine is injected to increase plasma levels of Factor IX and can temporarily correct this coagulation defect.
Benefix (Genetics Institute) for patients
Benefix (Genetics Institute) Interactions
Benefix (Genetics Institute) Contraindications
Because BeneFIX�, Coagulation Factor IX (Recombinant), is produced in a Chinese hamster ovary cell line, it may be contraindicated in patients with a known history of hypersensitivity to hamster protein..
Additional information about Benefix (Genetics Institute)
Benefix (Genetics Institute) Indication: For treatment of hemophilia (Christmas disease).
Mechanism Of Action: Cleaves the Arg-Ile bond in Factor X to form active factor Xa leading to coagulation and clotting.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Coagulation Factor IX
Synonyms: Christmas factor; Coagulation factor IX precursor; PTC; Plasma thromboplastin component
Drug Category: Coagulants; Thrombotic Agents
Drug Type: Biotech; Approved
Other Brand Names containing Coagulation Factor IX: Benefix (Genetics Institute);
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: 19.4 ± 5.4 hours (range from 11 to 36 hours)
Dosage Forms of Benefix (Genetics Institute): Injection, powder, lyophilized, for solution Intravenous
Chemical IUPAC Name: Human factor IX protein
Chemical Formula: C2041H3136N558O641S25
Coagulation Factor IX on Wikipedia: http://en.wikipedia.org/wiki/Factor_IX
Organisms Affected: Humans and other mammals