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Benylate

Benylate - General Information

Benzyl benzoate is one of the older preparations used to treat scabies. Scabies is a skin infection caused by the mite sarcoptes scabiei. It is characterised by severe itching (particularly at night), red spots, and may lead to a secondary infection. Benzyl benzoate is lethal to this mite and so is useful in the treatment of scabies. It is also used to treat lice infestation of the head and body. Benzyl benzoate is not the treatment of choice for scabies due to its irritant properties.

 

Pharmacology of Benylate

Benzyl benzoate is one of the older preparations used to treat scabies. Scabies is a skin infection caused by the mite sarcoptes scabiei. It is characterised by severe itching (particularly at night), red spots, and may lead to a secondary infection. Benzyl benzoate is lethal to this mite and so is useful in the treatment of scabies. It is also used to treat lice infestation of the head and body. Benzyl benzoate is not the treatment of choice for scabies due to its irritant properties.

 

Additional information about Benylate

Benylate Indication: Used to kill lice and the mites responsible for the skin condition scabies.
Mechanism Of Action: The mechanism behind benzyl benzoate's actions is not known. However, in light of the its effects on vertebrates, it is presumed that benzyl benzoate may act on the nervous system of the parasite, resulting in its death. In vitro, benzyl benzoate has been found to kill the Sarcoptes mite within 5 minutes.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Benzyl Benzoate
Synonyms: Not Available
Drug Category: Insecticides; Acaricides
Drug Type: Small Molecule; Approved
Other Brand Names containing Benzyl Benzoate: Ascabin; Ascabiol; Benylate; Benzoic acid benzyl ester; Benzoic acid, benzyl ester; Benzoic acid, phenylmethyl ester; Benzyl alcohol benzoic ester; Benzyl benzenecarboxylate; Benzyl benzoate 99+ %; Benzyl ester; Benzyl phenylformate; Benzylester kyseliny benzoove; Benzylets; Colebenz; Novoscabin; Peruscabin; Scabagen; Scabanca; Scabide; Scabiozon; Scabitox; Scobenol; Vanzoate; Venzoate; Venzonate;
Absorption: No data are available on percutaneous absorption of benzyl benzoate. Some older studies have suggested some percutaneous absorption, however the amount was not quantified.
Toxicity (Overdose): Oral, rabbit: LD50 = 1680 mg/kg; Skin, rabbit: LD50 = 4000 mg/kg. Symptoms of overdose include blister formation, crusting, itching, oozing, reddening, or scaling of skin; difficulty in urinating (dribbling); jerking movements; sudden loss of consciousness.
Protein Binding: Not Available
Biotransformation: Rapidly hydrolyzed to benzoic acid and benzyl alcohol, which is further oxidized to benzoic acid. The benzoic acid is conjugated with glycine to form hippuric acid.
Half Life: Not Available
Dosage Forms of Benylate: Not Available
Chemical IUPAC Name: phenylmethyl benzoate
Chemical Formula: C14H12O2
Benzyl Benzoate on Wikipedia: http://en.wikipedia.org/wiki/Benzyl_Benzoate
Organisms Affected: Sarcoptes scabiei