Cytokeratin-19 fragment (CYFRA 21-1)
Indications for cytokeratin-19 fragment (CYFRA 21-1) test:
- Non-small cell lung carcinoma and squamous cell lung carcinoma
- Monitoring of muscle-invasive bladder carcinoma
Cytokeratins — insoluble proteins of the cell skeleton, they are known more than 20. Cytokeratin-19 fragment (CYFRA 21-1) are soluble in the serum, have a molecular weight of 30,000 Da. In the test for a tumor marker used 2 monoclonal antibodies for the detection of a fragment of cytokeratin-19 fragment (CYFRA 21-1).
The norm of this tumor marker is 2.3 ng/ml.
Elevated levels of cytokeratin-19 fragment (CYFRA 21-1) are found in non-small cell lung carcinoma, squamous cell lung carcinoma, in muscle-invasive bladder carcinoma. A slight increase (up to 10 ng/ml) is observed in benign liver diseases and renal failure. It should be noted that contamination of blood samples by saliva leads to inflated results.