Navigation

Tissue polypeptide antigen (TPA) and tissue polypeptide specific antigen (TPS)

Tissue polypeptide antigen (TPA)

Indications for tissue polypeptide antigen (TPA) test:

  • bladder carcinoma monitoring

Tissue polypeptide antigen (TPA) — is proliferative antigen of keratin nature with a molecular weight of 22 000 Da. Found in most epithelial cells, in serum, in cell membranes of tumor cells. Normal value of tissue polypeptide antigen (TPA) — 85-120 U/ml.

Elevated levels of tissue polypeptide antigen (TPA) is observed in bladder carcinoma in patients with breast, bronchus, colorectal intestine and cervix carcinomas. The rise of the level of tissue polypeptide antigen (TPA) is detected and in some lung, liver and urogenital tract benign diseases.

Tissue polypeptide specific antigen (TPS)

Tissue polypeptide specific antigen (TPS) found in most epithelial cells, in the membranes of tumor cells and in serum. TPS is proliferation antigen.

Normal value of tissue polypeptide specific antigen (TPS) — 85-120 U/ml.

Elevated levels of tissue polypeptide specific antigen (TPS) has been observed in bladder, breast and bronchus carcinomas.

Despite the fact that tissue polypeptide specific antigen (TPS) is an active component of tissue polypeptide antigen (TPA), its sensitivity in some solid tumors is lower than tissue polypeptide antigen (TPA). In particular, for bladder and bronchi cancer it is two times lower than the sensitivity of TPA, and in non-small cell lung carcinoma — almost with three times lower sensitivity.