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Differential diagnosis of myoglobinuria

Myoglobinuria - is the appearance of myoglobin in the urine. Myoglobin - a protein pigment of muscle cells. Regarded as a primitive respiratory pigment, which performs the role of short-term muscle reserve of oxygen and is part of the transport of oxygen inside the cells. Myoglobinuria precedes mioglobinemiya.

Myoglobin is released in urine when its concentration in the blood reaches 9.12 mmol / liter. The urine becomes red, then 2-3 hours becomes brown, sharply acidic urine pH, proteinuria is detected, can be cylindruria.


Types of myoglobinuria

Identified the following types of myoglobinuria:

  • idiopathic myoglobinuria
  • Paroxysmal myoglobinuria
  • paralytic myoglobinuria
  • traumatic myoglobinuria, including after electric shock
  • myoglobinuria after being bitten by snakes, wasps
  • myoglobinuria as a consequence of ischemia of muscle tissue (infarction, thrombosis, embolism)
  • toxic myoglobinuria (alcohol poisoning, chemicals)
  • myoglobinuria in muscular dystrophy
  • myoglobinuria march, etc.

Massive myoglobinuria causes damage to the renal nephrons, which leads to the development of anuria and acute renal failure.
Myoglobin and hemoglobin - is the most related hromoproteiny. Therefore, chemical reactions on hemoglobin test positive and myoglobin.


Differential diagnosis of myoglobinuria

Criteria for differential diagnosis of myoglobinuria and hemoglobinuria:

  • with hemoglobinuria plasma painted, with myoglobinuria - no;
  • myoglobin in the urine appears faster, hemoglobin - the latest
  • myoglobin in the urine rapidly into metamioglobin and the urine (urine analysis test) becomes brown-brown color, with long stays urine hemoglobinuria cherry-red color (the color of "meat slops)
  • with myoglobinuria in urine sediment in the first day of absence corpuscles; hemoglobinuria during the first day in the urine sediment may appear hemosiderin, red blood cells, pigment cylinders
  • with myoglobinuria, unlike hemoglobinuria, does not show hemosiderin


If you have any questions about the diagnosis or treatment of myoglobinuria, you can specify them with our urologist or a nephrologist on the phone: +7 (926) 988-14-23



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