Purpurinuria - increase of porphyrins in the urine can be a symptom of porphyria or liver disease, intoxication, cytostatic therapy, infection, iron deficiency and hemolytic anemias, Hodgkin's disease, leukemia.
Porphyrins - a synthesis of heme intermediates (non-protein part of hemoglobin). They are formed from the amino acid glycine and succinic acid derivative - succinyl-coenzyme A. The basic amount of porphyrins synthesized in the bone marrow (for the formation of the heme of hemoglobin) and liver (for the synthesis of redox enzymes, the heme of myoglobin, myelin, bone and other tissues).
Normally, the urine a small amount of uro-and coproporphyrin. Strengthening the excretion of porphyrins (purpurinuria) is observed in lesions of the liver. A healthy liver is able to oxidize and release products of metabolism of porphyrins as a copro-and protoporphyrins with feces. When you turn off this road pigments back into the bloodstream, pass kidney filter and stand out in increased quantities in the urine (purpurinuria).
Alcohol intake, X-ray radiation, physical stress, hemolysis of red blood cells, myoglobinuria leading to increased levels of urine porphyrins (purpurinuria). In renal insufficiency, the content of porphyrins in the urine decreases.
Urinary excretion of porphobilinogen (PBG), urine stains in the red or pink color and is characteristic of acute intermittent porphyria, which is accompanied by lesions of the musculoskeletal, central and peripheral nervous system. Heterozygous form has a long latency for homozygous - severe polisindromnoe disease.
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