Amyotrophy is a term used to describe thinning or wasting (atrophy) of musculature with attendant weakness. This may result from involvement of:

  • Lower motor neurones (in which case fasciculations may also be present):
    • Amyotrophic lateral sclerosis
      Benign focal amyotrophy/monomelic amyotrophy Disinhibition-dementia-parkinsonism-amyotrophy complex (DDPAC)
      Amyotrophic Creutzfeldt-Jakob disease (obsolete term) "Asthmatic amyotrophy" (Hopkins’ syndrome)
  • Nerve roots:
    • Diabetic amyotrophy (polyradiculopathy, especially L2-L4)
  • Plexus:
    • Neuralgic amyotrophy (Parsonage-Turner syndrome)
      Hence although the term implies neurogenic (as opposed to myogenic) muscle wasting, its use is nonspecific with respect to neuroanatomical substrate.

Cross References

Atrophy; Fasciculation; Neuropathy; Plexopathy; Radiculopathy; Wasting