Metabolic bone disease
To understand the mechanisms of a disease of bone and bones in general, should carefully examine what the bone and the bone itself.
Bone - is a specialized connective tissue, which, like all the connective tissue contains cells and the extracellular matrix. Extracellular matrix consists of organic and inorganic material.
The organic part consists of proteins, of which 95% is type I collagen, is part of the fibrils. Non-collagenous proteins - is osteocalcin, osteonectin and osteorontin. Inorganic material is formed by calcium, phosphate, magnesium, hydroxyapatite. Cellular component represented by osteoblasts, osteocytes, osteoclasts.
Calcified bone matrix is not inert, it is an exchange process with the participation of bone cells - osteocytes, interconnected branches. Throughout life in different parts of the bone mineralized matrix is replaced by newly formed bone.
This process is called "remodeling", or "bone turnover". Impaired cycle of remodeling or regulation of the activity of bone cells leads to metabolic bone disease, including osteoporosis, hyperparathyroidism, neoplastic process, osteomalacion and Paget's disease.