Ascorb - General Information
A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Ascorb is considered an antioxidant.
Pharmacology of Ascorb
Ascorbic Acid (vitamin C) is a water-soluble vitamin indicated for the prevention and treatment of scurvy, as ascorbic acid deficiency results in scurvy. Collagenous structures are primarily affected, and lesions develop in bones and blood vessels. Administration of ascorbic acid completely reverses the symptoms of ascorbic acid deficiency.
Ascorb for patients
Limited evidence suggests that ascorbic acid may influence the intensity and duration of action of bishydroxycoumarin.
There are no contraindications to the administration of ascorbic acid.
Additional information about Ascorb
Ascorb Indication: Used to treat vitamin C deficiency, scurvy, delayed wound and bone healing, urine acidification, and in general as an antioxidant. It has also been suggested to be an effective antiviral agent.
Mechanism Of Action: In humans, an exogenous source of ascorbic acid is required for collagen formation and tissue repair by acting as a cofactor in the posttranslational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins. Ascorbic acid is reversibly oxidized to dehydroascorbic acid in the body. These two forms of the vitamin are believed to be important in oxidation-reduction reactions. The vitamin is involved in tyrosine metabolism, conversion of folic acid to folinic acid, carbohydrate metabolism, synthesis of lipids and proteins, iron metabolism, resistance to infections, and cellular respiration.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Vitamin C
Synonyms: AA; Ascorbic Acid; L-Ascorbate; L-Ascorbic Acid; Ascorbate; L-Lyxoascorbic Acid; L-Xyloascorbic Acid
Drug Category: Antioxidants; Essential Vitamins; Free Radical Scavengers; Vitamins (Vitamin C)
Drug Type: Small Molecule; Nutraceutical; Approved
Absorption: 70% to 90%
Toxicity (Overdose): Not Available
Protein Binding: 25%
Biotransformation: Hepatic. Ascorbic acid is reversibly oxidised (by removal of the hydrogen from the enediol group of ascorbic acid) to dehydroascorbic acid. The two forms found in body fluids are physiologically active. Some ascorbic acid is metabolized to inactive compounds including ascorbic acid-2-sulfate and oxalic acid.
Half Life: 16 days (3.4 hours in people who have excess levels of vitamin C)
Dosage Forms of Ascorb: Tablet Oral
Tablet, extended release Oral
Powder, for solution Oral
Capsule, extended release Oral
Tablet, effervescent Oral
Tablet, chewable Oral
Bar, chewable Oral
Solution / drops Oral
Chemical IUPAC Name: (2R)-2-[(1S)-1,2-dihydroxyethyl]-4,5-dihydroxyfuran-3-one
Chemical Formula: C6H8O6
Vitamin C on Wikipedia: https://en.wikipedia.org/wiki/Vitamin_C
Organisms Affected: Humans and other mammals