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Candoxatrilat

Candoxatrilat - General Information

Candoxatrilat is the orally-active prodrug of candoxatrilat (UK-73967), the active enantiomer of candoxatrilat (UK-69578), a potent neutral endopeptidase (NEP) inhibitor used in the treatment of chronic heart failure.

 

Pharmacology of Candoxatrilat

Candoxatrilat is the orally-active prodrug of candoxatrilat (UK-73967), the active enantiomer of candoxatrilat (UK-69578), a potent neutral endopeptidase (NEP) inhibitor used in the treatment of chronic heart failure in man.

 

Additional information about Candoxatrilat

Candoxatrilat Indication: For treatment of hypertension, improve exercise capacity in patients with CHF receiving angiotensin converting enzyme inhibition.
Mechanism Of Action: Neutral endopeptidase inhibitors such as Candoxatrilat have a dual mechanism of action. They inhibit two metalloprotease enzymes, neutral endopeptidase and ACE, resulting in an increased availability of natriuretic peptides that exhibit vasodilatory effects and, possibly, tissue protective effects.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Candoxatril
Synonyms: Not Available
Drug Category: Prodrugs; Antihypertensive Agents
Drug Type: Small Molecule; Approved
Other Brand Names containing Candoxatril: Candoxatrilat;
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Candoxatrilat: Not Available
Chemical IUPAC Name: 4-[[1-[(2S)-3-(2,3-dihydro-1H-inden-5-yloxy)-2-(2-methoxyethoxymethyl)-3-oxopropyl]cyclopentanecarbonyl]amino]cyclohexane-1-carboxylic acid
Chemical Formula: C29H41NO7
Candoxatril on Wikipedia: Not Available
Organisms Affected: Humans and other mammals