Centyl - General Information
A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p810)
Pharmacology of Centyl
Centyl, a thiazide diuretic, removes excess water from the body by increasing how often you urinate (pass water) and also widens the blood vessels which helps to reduce blood pressure. It inhibits Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue.
Centyl for patients
May interact with the following: cholestyramine, colestipol (use with thiazide diuretics may prevent the diuretic from working properly; take the diuretic at least 1 hour before or 4 hours after cholestyramine or colestipol), digitalis glycosides (use with thiazide diuretics may cause high blood levels of digoxin, which may increase the chance of side effects), and lithium (use with thiazide diuretics may cause high blood levels of lithium, which may increase the chance of side effects).
Contraindicated in the following: diabetes mellitus (thiazide diuretics may increase the amount of sugar in the blood), gout (history of), lupus erythematosus (history of), pancreatitis (thiazide diuretics may make these conditions worse), heart or blood vessel disease (thiazide diuretics may cause high cholesterol levels or high triglyceride levels), liver disease, and kidney disease (higher blood levels of the thiazide diuretic may occur, which may prevent the thiazide diuretic from working properly).
Additional information about Centyl
Centyl Indication: For the treatment of high blood pressure and management of edema
Mechanism Of Action: As a diuretic, bendroflumethiazide inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water. Thiazides like bendroflumethiazide also inhibit sodium ion transport across the renal tubular epithelium through binding to the thiazide sensitive sodium-chloride transporter. This results in an increase in potassium excretion via the sodium-potassium exchange mechanism. The antihypertensive mechanism of bendroflumethiazide is less well understood although it may be mediated through its action on carbonic anhydrases in the smooth muscle or through its action on the large-conductance calcium-activated potassium (KCa) channel, also found in the smooth muscle.
Drug Interactions: Amantadine The diuretic increases the adverse effect of amantadine
Deslanoside Possible electrolyte variations and arrhythmias
Diazoxide Significant hyperglycemic effect
Digoxin Possible electrolyte variations and arrhythmias
Dofetilide Increased risk of cardiotoxicity and arrhythmias
Lithium The thiazide diuretic increases serum levels of lithium
Digitoxin Possible electrolyte variations and arrhythmias
Food Interactions: Take with food to increase bioavailability.
Generic Name: Bendroflumethiazide
Synonyms: Bendroflumethazide; Bendroflumethiazidum [Inn-Latin]; Bendroflumetiazida [Inn-Spanish]; Bendrofumethiazide; Bendrofluazide; Benzhydroflumethiazide; Benzydroflumethiazide; Benzylhydroflumethiazide; BHFT
Drug Category: Diuretics, Thiazide; Antihypertensive Agents
Drug Type: Small Molecule; Approved
Absorption: Absorbed relatively rapidly after oral administration
Toxicity (Overdose): Not Available
Protein Binding: 96%
Biotransformation: Not Available
Half Life: 8.5 hours
Dosage Forms of Centyl: Not Available
Chemical IUPAC Name: 1,1-dioxo-3-(phenylmethyl)-6-(trifluoromethyl)-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide
Chemical Formula: C15H14F3N3O4S2
Bendroflumethiazide on Wikipedia: https://en.wikipedia.org/wiki/Bendroflumethiazide
Organisms Affected: Humans and other mammals