Cervidil - General Information

Cervidil, is a naturally occurring prostaglandin E2 (PGE2). It has important effects in labour. It also stimulates osteoblasts to release factors which stimualtes bone resorption by osteoclasts. As a prescription drug it is used as a vaginal suppository, to prepare the cervix for labour and to induce labour.


Pharmacology of Cervidil

Cervidil is equivalent to prostaglandin E2 (PGE2). It stimulates labor and delivery and thus terminates pregnancy. Cervidil is also capable of stimulating the smooth muscle of the gastrointestinal tract of man. This activity may be responsible for the vomiting and/or diarrhea that is not uncommon when dinoprostone is used to terminate pregnancy.


Cervidil for patients


Cervidil Interactions

PROSTIN E2 may augment the activity of other oxytocic drugs. Concomitant use with other oxytocic agents is not recommended.


Cervidil Contraindications

  1. Hypersensitivity to dinoprostone
  2. Acute pelvic inflammatory disease
  3. Patients with active cardiac, pulmonary, renal, or hepatic disease


Additional information about Cervidil

Cervidil Indication: For the termination of pregnancy from the 12th through the 20th gestational week as calculated from the first day of the last normal menstrual period. Also for evacuation of the uterine contents in the management of missed abortion or intrauterine fetal death up to 28 weeks of gestational age as calculated from the first day of the last normal menstrual period, and also used in the management of nonmetastatic gestational trophoblastic disease (benign hydatidiform mole).
Mechanism Of Action: Cervidil administered intravaginally stimulates the myometrium of the gravid uterus to contract in a manner that is similar to the contractions seen in the term uterus during labor, resulting in the evacuation of the products of conception from the uterus.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Dinoprostone
Synonyms: Dinoprostone Prostaglandin E2; PGE2; Prostaglandin E2
Drug Category: Oxytocics; Prostaglandins
Drug Type: Small Molecule; Approved

Other Brand Names containing Dinoprostone: Cervidil; Prepidil; Prostarmon E; Prostin E; Prostin E2; Propess;
Absorption: Absorbed at a rate of 0.3 mg per hour over 12 hours while the vaginal system is in place.
Toxicity (Overdose): Oral, mouse: LD50 = 750 mg/kg; Oral, rat: LD50 = 500 mg/kg.
Protein Binding: 73%, to albumin
Biotransformation: Rapid metabolism of dinoprostone occurs primarily in the local tissues; any systemic absorption of the medication is cleared mainly in the maternal lungs and, secondarily, at sites such as the liver and kidneys.
Half Life: Less than 5 minutes.
Dosage Forms of Cervidil: Insert Intravaginal
Tablet Oral
Gel Endocervical (intracervical)
Gel Intravaginal
Chemical IUPAC Name: 7-[(1R,2R,3R)-3-hydroxy-2-[(3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]hept-5-enoic acid
Chemical Formula: C20H32O5
Dinoprostone on Wikipedia:
Organisms Affected: Humans and other mammals