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Chymex

Chymex - General Information

Chymex is a peptide used as a screening test for exocrine pancreatic insufficiency and to monitor the adequacy of supplemental pancreatic therapy. It is given by mouth as a noninvasive test. The amount of 4-aminobenzoic acid and its metabolites excreted in the urine is taken as a measure of the chymotrypsin-secreting activity of the pancreas. Headache and gastrointestinal disturbances have been reported in patients taking bentiromide. Chymex is not available in the U.S. or Canada (It was withdrawn in the US in October 1996).

 

Pharmacology of Chymex

Chymex is a peptide used as a screening test for exocrine pancreatic insufficiency and to monitor the adequacy of supplemental pancreatic therapy. It is given by mouth as a noninvasive test. The amount of p-aminobenzoic acid and its metabolites excreted in the urine is taken as a measure of the chymotrypsin-secreting activity of the pancreas. Headache and gastrointestinal disturbances have been reported in patients taking bentiromide. Chymex is not available in the U.S. or Canada.

 

Chymex for patients

How the test is done: Bentiromide is given by mouth as a single dose. After you take bentiromide, all of your urine is collected for the next six hours. The total amount is measured and a small sample is saved and examined. Your doctor may repeat the test after seven days.

 

Chymex Interactions

Bentiromide may interact with acetaminophen (e.g., Tylenol), chloramphenicol (e.g., Chloromycetin), local anesthetics (e.g., benzocaine and lidocaine), para-aminobenzoic acid (PABA)-containing preparations (e.g., sunscreens and some multivitamins), procainamide (e.g., Pronestyl), sulfonamides (sulfa medicines), thiazide diuretics (use of these medicines during the test period will affect the test results), and pancreatic supplements (use of pancreatic supplements may give false test results).

 

Chymex Contraindications

Bentiromide is contraindicated in disease of the stomach and intestines, kidney disease, and liver disease as these medical problems may cause false test results.

 

Additional information about Chymex

Chymex Indication: Used as a screening test for exocrine pancreatic insufficiency and to monitor the adequacy of supplemental pancreatic therapy.
Mechanism Of Action: Chymex is a peptide that is broken down in the pancreas by lipase, protease, and amylase. By determining the output of unchanged bentiromide in the urine following oral administration, it is possible to determine the sufficiency of pancreatic activity.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Bentiromide
Synonyms: Bentiromide [USAN-BAN-INN-JAN]; Bentiromido [INN-Spanish]; Bentiromidum [INN-Latin]; BTPABA; PFD; PFT
Drug Category: Diagnostic aids
Drug Type: Small Molecule; Approved
Other Brand Names containing Bentiromide: Chymex;
Absorption: Not Available
Toxicity (Overdose): Symptoms of overdose include shortness of breath and troubled breathing.
Protein Binding: Not Available
Biotransformation: Primarily hepatic. Enzymatic activity capable of hydrolyzing bentiromide has also been found in normal small intestine.
Half Life: Not Available
Dosage Forms of Chymex: Not Available
Chemical IUPAC Name: 4-[[2-(benzoylamino)-3-(4-hydroxyphenyl)propanoyl]amino]benzoic acid
Chemical Formula: C23H20N2O5
Bentiromide on Wikipedia: https://en.wikipedia.org/wiki/Bentiromide
Organisms Affected: Humans and other mammals