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Citopan

Citopan - General Information

A barbiturate that is effective as a hypnotic and sedative.

 

Pharmacology of Citopan

Citopan is a barbiturate derivative having hypnotic and sedative effects. It was used in the 1940s-1950s as an agent for inducing anesthesia for surgery and has a relatively fast onset of effects and short duration of action. However it can be difficult to control the depth of anesthesia with hexobarbital which makes it quite dangerous, and it has now been replaced by safer drugs in human medicine, usually thiopental would be the barbiturate of choice for this application these days.

 

Citopan for patients

 

Citopan Interactions

Barbiturates may decrease the effectiveness of oral contraceptives, certain antibiotics, quinidine, theophylline, corticosteroids, anticoagulants, and beta blockers.

 

Citopan Contraindications

 

Additional information about Citopan

Citopan Indication: For the induction of anesthesia prior to the use of other general anesthetic agents and for induction of anesthesia for short surgical, diagnostic, or therapeutic procedures associated with minimal painful stimuli.
Mechanism Of Action: Citopan binds at a distinct binding site associated with a Cl- ionopore at the GABA-A receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Hexobarbital
Synonyms: Hexobarbitone; 5-(1-cyclohexen-1-yl)-1,5-dimethylbarbituric acid; Methexenyl; Methylhexabital
Drug Category: Hypnotics and Sedatives; Adjuvants; Barbiturates
Drug Type: Small Molecule; Approved

Other Brand Names containing Hexobarbital: Citopan; Evipan; Noctivane; Sombucaps; Sombulex; Somnalert; Evipal; Cyclopan; Cyclopal; Barbidorm;
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: 25%
Biotransformation: Hepatic.
Half Life: Not Available
Dosage Forms of Citopan: Tablet Oral
Chemical IUPAC Name: 5-(1-cyclohexenyl)-1,5-dimethyl-1,3-diazinane-2,4,6-trione
Chemical Formula: C12H16N2O3
Hexobarbital on Wikipedia: https://en.wikipedia.org/wiki/Hexobarbital
Organisms Affected: Humans and other mammals