Clindagel - General Information
An antibacterial agent that is a semisynthetic analog of lincomycin.
Pharmacology of Clindagel
Clindagel is an antibiotic, similar to and a derivative of lincomycin. Clindagel can be used in topical or systemic treatment. It is effective as an anti-anaerobic antibiotic and antiprotozoal.
Clindagel for patients
This medicine is used to treat various bacterial infections, such as pneumonia
or other respiratory conditions such as COPD. It can also by used in patients
with cystic fibrosis or patients who have received an infection while being
hospitalized, or who have bacteria in the blood (bacteremia). In children,
this medicine is commonly used to treat ear infections (otitis media), pneumonia,
sore throat (pharyngitis) or tonsillitis. Take the medicine orally as directed.
This medicine can be taken with or without food. And remember to finish all medication
unless your doctor has advised you otherwise. It is also important to avoid taking
aluminum or magnesium-containing antacids together with this medicine. If you take
antacids, separate them from your antibiotic by at least 2 hours.
Clindamycin has been shown to have neuromuscular blocking properties that may enhance the action of other neuromuscular blocking agents. Therefore, it should be used with caution in patients receiving such agents. Antagonism has been demonstrated between clindamycin and erythromycin in vitro. Because of possible clinical significance, these two drugs should not be administered concurrently.
Clindamycin hydrochloride is contraindicated in individuals with a history of hypersensitivity to preparations containing clindamycin or lincomycin.
Additional information about Clindagel
Clindagel Indication: For the treatment of serious infections caused by susceptible anaerobic bacteria (anaerobes, streptococci, pneumococci, and staphylococci)
Mechanism Of Action: Systemic/Vaginal-Clindagel inhibits protein synthesis of bacteria by binding to the 50 S ribosomal subunits of the bacteria. Topical-Clindagel reduces free fatty acid concentrations on the skin and to suppress the growth of Propionibacterium acnes (Corynebacterium acnes), an anaerobe found in sebaceous glands and follicles.
Drug Interactions: Aluminium The aluminium salt decreases the absorption of lincosamides
Atracurium The agent increases the effect of muscle relaxant
Dihydroxyaluminium The aluminium salt decreases the absorption of lincosamides
Cyclosporine Decreases the effect of cyclosporine
Doxacurium The agent increases the effect of muscle relaxant
Gallamine Triethiodide The agent increases the effect of muscle relaxant
Metocurine The agent increases the effect of muscle relaxant
Mivacurium The agent increases the effect of muscle relaxant
Pancuronium The agent increases the effect of muscle relaxant
Pipecuronium The agent increases the effect of muscle relaxant
Rocuronium The agent increases the effect of muscle relaxant
Succinylcholine The agent increases the effect of muscle relaxant
Tubocurarine The agent increases the effect of muscle relaxant
Vecuronium The agent increases the effect of muscle relaxant
Attapulgite The aluminium salt decreases the absorption of lincosamides
Kaolin The aluminium salt decreases the absorption of lincosamides
Food Interactions: Take with food.
Generic Name: Clindamycin
Synonyms: Clindamycin Hcl; Clindamicina [Inn-Spanish]; Clindamycin Hydrochloride; Clindamycin Phosphate; Clindamycine [French]; Clindamycine [Inn-French]; Clindamycinum [Inn-Latin]
Drug Category: Anti-Bacterial Agents; Lincomycins
Drug Type: Small Molecule; Approved; Investigational
Absorption: Rapidly absorbed after oral administration. Absorption of an oral dose is virtually complete (90%), and the concomitant administration of food does not appreciably modify the serum concentrations; serum levels have been uniform and predictable from person to person and dose to dose.
Toxicity (Overdose): Orally and parenterally administered clindamycin has been associated with severe colitis (pseudomembranous colitis) which may result in patient death. Use of the topical formulation of clindamycin results in absorption of the antibiotic from the skin surface. Diarrhea, bloody diarrhea, and colitis (including pseudomembranous colitis) have been reported with the use of topical and systemic clindamycin.
Protein Binding: 92-94%
Half Life: 2.4 hours
Dosage Forms of Clindagel: Solution Intravenous
Powder, for solution Oral
Chemical IUPAC Name: (2S,4R)-N-[2-chloro-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-methylsulfanyloxan-2-yl]propyl]-1-methyl-4-propylpyrrolidine-2-carboxamide
Chemical Formula: C18H33ClN2O5S
Clindamycin on Wikipedia: https://en.wikipedia.org/wiki/Clindamycin
Organisms Affected: Enteric bacteria and other eubacteria