Clobetasole propionate - General Information
A derivative of prednisolone with high glucocorticoid activity and low mineralocorticoid activity. Absorbed through the skin faster than fluocinonide, it is used topically in treatment of psoriasis but may cause marked adrenocortical suppression.
Pharmacology of Clobetasole propionate
Like other topical corticosteroids, clobetasol has anti-inflammatory, antipruritic, and vasoconstrictive properties. It is a very high potency topical corticosteroid that should not be used with occlusive dressings. It is recommended that treatment should be limited to 2 consecutive weeks and therapy should be discontinued when adequate results have been achieved.
Clobetasole propionate for patients
Your doctor has prescribed OLUX Foam for the relief of dermatoses of the scalp, such as psoriasis. OLUX Foam works because its active ingredient is clobetasol propionate, 0.05%. Clobetasol propionate belongs to a group of medicines known as topical corticosteroids. These agents are used to reduce the inflammation, redness, swelling, itching, and tenderness associated with dermatologic conditions.
Other ingredients in OLUX Foam include ethanol, purified water, propylene glycol, cetyl alcohol, stearyl alcohol, polysorbate 60, citric acid, and potassium citrate. The foam is dispensed from an aluminum can that is pressurized by a hydrocarbon propellant (propane and butane).
If you answer YES to one or more of the following questions, tell your doctor (or pharmacist) before using this medicine, so you can get advice about what to do.
· Are you allergic to any of the ingredients contained in OLUX Foam?
· Are you pregnant? Planning on becoming pregnant while using OLUX Foam? Or are you breastfeeding?
· Do you think you have an infection on your scalp?
How to apply OLUX Foam
Turn the can upside down and dispense a small amount of OLUX Foam into the cap of the can, onto a clean saucer or other cool, clean surface, or directly onto the lesion, taking care to avoid contact with the eyes. Dispensing directly onto hands is not recommended, as the foam will begin to melt immediately upon contact with warm skin.
Move the hair away from the affected area of your scalp so that the foam can be applied to each affected area. Gently massage into the affected scalp area until the foam disappears. Repeat until entire affected scalp area is treated.
Apply twice daily, once in the morning and once at night. Use only enough to cover the affected areas.
Wash your hands after applying OLUX Foam and discard any unused dispensed medication.
Do not wash or rinse the treated areas immediately after applying OLUX Foam.
· Use this medication only for the condition for which it was prescribed. OLUX Foam should not be applied to the face, groin, or armpits.
· OLUX Foam is for external use only.
· Keep the foam away from your eyes, as it will sting. If the foam gets into your eyes, rinse well with cold water. If the stinging continues, contact your doctor immediately.
WHAT YOU SHOULD KNOW ABOUT OLUX FOAM:
What to do if you miss an application
If you forget to apply OLUX Foam at the scheduled time, use it as soon as you remember, and then go back to your regular schedule. If you remember at or about the time of your next daily application, apply that dose and continue with your normal application schedule. If you miss several doses, tell your doctor.
About side effects
As with all medications, there may be some side effects. The most frequent side effects associated with the use of clobetasol propionate formulations include mild burning, stinging, or itching at the site of application. These side effects typically disappear shortly after application.
Let your doctor know if you notice any of the following:
· Any unusual effects that you do not understand.
· Affected areas that do not seem to be healing after 2 weeks of using the foam.
Important safety notes
· The treated areas should not be bandaged or covered unless directed by your doctor.
· Keep this and all medicines out of the reach of children.
· Treatment should be limited to 2 consecutive weeks.
· Treatment should be limited to no more than 50 g of medication per week.
· Use in patients under 12 years of age is not recommended.
· Keep the foam away from your eyes.
· Store the can at controlled room temperature, 68-77°F (20-25°C), and protect it from direct sunlight, as this is a pressurized container.
· Keep away from and do not spray near fire, open flame, or direct heat-this product is flammable. Do not smoke while using or holding the can. Keep the can away from all sources of ignition. Do not pierce or burn the can, and never throw the can in a fire, even if empty.
· When you have finished your treatment, dispose of the can safely. A completely empty can is recyclable.
· Do not use the foam after the expiration date shown on the bottom of the can.
· Do not give OLUX Foam to anyone else. Your doctor has prescribed this medicine for your use only.
This pamphlet has been designed to provide you with important information about OLUX Foam, but does not address every aspect of the foam. If, after reading this pamphlet, you have any questions or concerns, please speak with your doctor or pharmacist.
Clobetasole propionate Interactions
No separate information availabl.
Clobetasole propionate Contraindications
OLUX Foam is contraindicated in patients who are hypersensitive to clobetasol propionate, to other corticosteroids, or to any ingredient in this preparation.
Additional information about Clobetasole propionate
Clobetasole propionate Indication: For short-term topical treatment of the inflammatory and pruritic manifestations of moderate to severe corticosteroid-responsive dermatoses of the scalp.
Mechanism Of Action: The precise mechanism of the antiinflammatory activity of topical steroids in the treatment of steroid-responsive dermatoses, in general, is uncertain. However, corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Clobetasol
Synonyms: Not Available
Drug Category: Corticosteroids, topical
Drug Type: Small Molecule; Approved
Other Brand Names containing Clobetasol: Clobesol; Clobetasol Propionate; Clobetasol propionate [USAN:JAN]; Clobetasole propionate; Clobetasolpropionat mikron.; Clobex; Dermovate; Embeline; Embeline E; Olux; Temovate; Temovate E;
Absorption: Topical corticosteroids can be absorbed from intact healthy skin. The extent of percutaneous absorption of topical corticosteroids is determined by many factors, including the vehicle and the integrity of the epidermal barrier. Occlusion, inflammation and/or other disease processes in the skin may also increase percutaneous absorption.
Toxicity (Overdose): Oral LD50 in rat and mouse is >3000 mg/kg. Topically applied clobetasol can be absorbed in sufficient amounts to produce systemic effects. Symptoms of overdose include thinning of skin and suppression of adrenal cortex (decreased ability to respond to stress).
Protein Binding: Not Available
Biotransformation: Metabolized, primarily in the liver, and then excreted by the kidneys.
Half Life: Not Available
Dosage Forms of Clobetasole propionate: Liquid Topical
Chemical IUPAC Name: [(8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate
Chemical Formula: C25H32ClFO5
Clobetasol on Wikipedia: https://en.wikipedia.org/wiki/Clobetasol
Organisms Affected: Humans and other mammals