Clorepin - General Information

Clorepin is a drug which is a benzodiazepine derivative. It has been marketed as an anxiolytic since 1975 and an anticonvulsant since 1984. [Wikipedia]


Pharmacology of Clorepin

Clorepin is a barbiturate used in combination with acetaminophen or aspirin and caffeine for its sedative and relaxant effects in the treatment of tension headaches, migraines, and pain.


Clorepin for patients


Clorepin Interactions

Alcohol (increases bioavailability by 50%), cimetidine, and valproates.


Clorepin Contraindications

Myasthenia gravis, sleep apnea, severe liver diseases such as cirrhosis and hepatitis, and respiratory problems.


Additional information about Clorepin

Clorepin Indication: For treatment and management of epilepsy and anxiety disorder.
Mechanism Of Action: Clorepin binds at a distinct binding site associated with a Cl- ionopore at the GABA-A receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is prolonged as a result.
Drug Interactions: Clozapine Increased risk of toxicity
Kava Kava increases the effect of the benzodiazepine
Food Interactions: Take without regard to meals.
Alcohol increases clobazam absorption by 50%.
Generic Name: Clobazam
Synonyms: Not Available
Drug Category: Anticonvulsants; Benzodiazepines
Drug Type: Small Molecule; Illicit; Approved; Investigational

Other Brand Names containing Clobazam: Chlorepin; Clorepin; Frisium; Mystan; Urbadan; Urbanyl;
Absorption: Bioavailability is 90%.
Toxicity (Overdose): Not Available
Protein Binding: 83%
Biotransformation: Hepatic. Clobazam has two major metabolites: N-desmethyl-clobazam and 4'-hydroxyclobazam, the former of which is active. The demethylation is facilitated by CYP2C19, CYP3A4, and CYP2B6 and the 4'-hydroxyclobazam by CYP2C18 and CYP2C19.
Half Life: 18 hours
Dosage Forms of Clorepin: Tablet Oral
Chemical IUPAC Name: 8-chloro-5-methyl-1-phenyl-1,5-benzodiazepine-2,4-dione
Chemical Formula: C16H13ClN2O2
Clobazam on Wikipedia:
Organisms Affected: Humans and other mammals