Clorepin - General Information
Clorepin is a drug which is a benzodiazepine derivative. It has been marketed as an anxiolytic since 1975 and an anticonvulsant since 1984. [Wikipedia]
Pharmacology of Clorepin
Clorepin for patients
Alcohol (increases bioavailability by 50%), cimetidine, and valproates.
Myasthenia gravis, sleep apnea, severe liver diseases such as cirrhosis and hepatitis, and respiratory problems.
Additional information about Clorepin
Clorepin Indication: For treatment and management of epilepsy and anxiety disorder.
Mechanism Of Action: Clorepin binds at a distinct binding site associated with a Cl- ionopore at the GABA-A receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is prolonged as a result.
Drug Interactions: Clozapine Increased risk of toxicity
Kava Kava increases the effect of the benzodiazepine
Food Interactions: Take without regard to meals.
Alcohol increases clobazam absorption by 50%.
Generic Name: Clobazam
Synonyms: Not Available
Drug Category: Anticonvulsants; Benzodiazepines
Drug Type: Small Molecule; Illicit; Approved; Investigational
Absorption: Bioavailability is 90%.
Toxicity (Overdose): Not Available
Protein Binding: 83%
Biotransformation: Hepatic. Clobazam has two major metabolites: N-desmethyl-clobazam and 4'-hydroxyclobazam, the former of which is active. The demethylation is facilitated by CYP2C19, CYP3A4, and CYP2B6 and the 4'-hydroxyclobazam by CYP2C18 and CYP2C19.
Half Life: 18 hours
Dosage Forms of Clorepin: Tablet Oral
Chemical IUPAC Name: 8-chloro-5-methyl-1-phenyl-1,5-benzodiazepine-2,4-dione
Chemical Formula: C16H13ClN2O2
Clobazam on Wikipedia: https://en.wikipedia.org/wiki/Clobazam
Organisms Affected: Humans and other mammals